Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2408528..2409503 | Replicon | chromosome |
| Accession | NZ_AP022927 | ||
| Organism | Bacillus cereus strain J2 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | L6497_RS12345 | Protein ID | WP_052494343.1 |
| Coordinates | 2408528..2409265 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | C2VTW9 |
| Locus tag | L6497_RS12350 | Protein ID | WP_000588936.1 |
| Coordinates | 2409378..2409503 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6497_RS12320 (BCJMU02_2391) | 2404038..2404739 | + | 702 | WP_001294994.1 | hypothetical protein | - |
| L6497_RS12325 (BCJMU02_2392) | 2404859..2405743 | + | 885 | WP_042512702.1 | hypothetical protein | - |
| L6497_RS12330 (BCJMU02_2393) | 2406063..2406845 | - | 783 | Protein_2357 | thiamine pyrophosphate-binding protein | - |
| L6497_RS12335 (BCJMU02_2394) | 2406952..2407434 | + | 483 | WP_042512701.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| L6497_RS12340 (BCJMU02_2395) | 2407602..2408339 | + | 738 | WP_236793561.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| L6497_RS12345 (BCJMU02_2396) | 2408528..2409265 | + | 738 | WP_052494343.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| L6497_RS12350 (BCJMU02_2397) | 2409378..2409503 | + | 126 | WP_000588936.1 | hypothetical protein | Antitoxin |
| L6497_RS12355 (BCJMU02_2398) | 2409526..2409756 | + | 231 | WP_272884633.1 | stage II sporulation protein SB | - |
| L6497_RS12360 (BCJMU02_2399) | 2409793..2410074 | - | 282 | WP_001041554.1 | hypothetical protein | - |
| L6497_RS30055 (BCJMU02_2400) | 2410297..2410431 | + | 135 | WP_272884478.1 | hypothetical protein | - |
| L6497_RS12365 (BCJMU02_2401) | 2410508..2410684 | + | 177 | WP_042512697.1 | stage II sporulation protein SB | - |
| L6497_RS12370 (BCJMU02_2402) | 2410828..2412297 | + | 1470 | WP_042512696.1 | beta-Ala-His dipeptidase | - |
| L6497_RS12375 (BCJMU02_2403) | 2412879..2413349 | - | 471 | WP_000670597.1 | DUF5065 family protein | - |
| L6497_RS12380 (BCJMU02_2404) | 2413526..2414146 | + | 621 | WP_127813147.1 | SGNH/GDSL hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28358.10 Da Isoelectric Point: 8.9957
>T36646 WP_052494343.1 NZ_AP022927:2408528-2409265 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T36646 NZ_AP022927:2408528-2409265 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATTGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACAAAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAAGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACCATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATTGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACAAAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAAGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACCATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4888.29 Da Isoelectric Point: 3.9798
>AT36646 WP_000588936.1 NZ_AP022927:2409378-2409503 [Bacillus cereus]
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK
Download Length: 126 bp
>AT36646 NZ_AP022927:2409378-2409503 [Bacillus cereus]
GTGATAAAAGAGAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA
GTGATAAAAGAGAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|