Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2361042..2362017 | Replicon | chromosome |
| Accession | NZ_AP022907 | ||
| Organism | Bacillus cereus strain MRY14-0100 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | L6498_RS12135 | Protein ID | WP_052494343.1 |
| Coordinates | 2361042..2361779 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | C2VTW9 |
| Locus tag | L6498_RS12140 | Protein ID | WP_000588936.1 |
| Coordinates | 2361892..2362017 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6498_RS12110 (BCM0100_2340) | 2356536..2357237 | + | 702 | WP_001294994.1 | hypothetical protein | - |
| L6498_RS12115 (BCM0100_2341) | 2357363..2358247 | + | 885 | WP_000795513.1 | hypothetical protein | - |
| L6498_RS12120 | 2358555..2359359 | - | 805 | Protein_2312 | thiamine pyrophosphate-binding protein | - |
| L6498_RS12125 (BCM0100_2344) | 2359466..2359948 | + | 483 | WP_000191909.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| L6498_RS12130 (BCM0100_2345) | 2360116..2360853 | + | 738 | WP_042512700.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| L6498_RS12135 (BCM0100_2346) | 2361042..2361779 | + | 738 | WP_052494343.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| L6498_RS12140 (BCM0100_2347) | 2361892..2362017 | + | 126 | WP_000588936.1 | hypothetical protein | Antitoxin |
| L6498_RS12145 (BCM0100_2348) | 2362094..2362270 | + | 177 | WP_061681843.1 | stage II sporulation protein SB | - |
| L6498_RS12150 (BCM0100_2349) | 2362307..2362588 | - | 282 | WP_001041554.1 | hypothetical protein | - |
| L6498_RS12155 (BCM0100_2351) | 2363021..2363197 | + | 177 | WP_042512697.1 | stage II sporulation protein SB | - |
| L6498_RS12160 (BCM0100_2352) | 2363341..2364810 | + | 1470 | WP_236804481.1 | beta-Ala-His dipeptidase | - |
| L6498_RS12165 (BCM0100_2353) | 2365392..2365862 | - | 471 | WP_236804483.1 | DUF5065 family protein | - |
| L6498_RS12170 (BCM0100_2354) | 2366315..2366974 | + | 660 | WP_236804485.1 | CatB-related O-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28358.10 Da Isoelectric Point: 8.9957
>T36640 WP_052494343.1 NZ_AP022907:2361042-2361779 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T36640 NZ_AP022907:2361042-2361779 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATTGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACAAAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAAGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACCATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATTGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACAAAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAAGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACCATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4888.29 Da Isoelectric Point: 3.9798
>AT36640 WP_000588936.1 NZ_AP022907:2361892-2362017 [Bacillus cereus]
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK
Download Length: 126 bp
>AT36640 NZ_AP022907:2361892-2362017 [Bacillus cereus]
GTGATAAAAGAGAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA
GTGATAAAAGAGAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|