Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2395743..2396718 | Replicon | chromosome |
| Accession | NZ_AP022886 | ||
| Organism | Bacillus cereus strain MRY14-0074 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | L6477_RS12370 | Protein ID | WP_061681849.1 |
| Coordinates | 2395743..2396480 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | C2VTW9 |
| Locus tag | L6477_RS12375 | Protein ID | WP_000588936.1 |
| Coordinates | 2396593..2396718 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6477_RS12345 (BCM0074_2401) | 2391251..2391952 | + | 702 | WP_001294994.1 | hypothetical protein | - |
| L6477_RS12350 (BCM0074_2402) | 2392074..2392958 | + | 885 | WP_042512702.1 | hypothetical protein | - |
| L6477_RS12355 (BCM0074_2403) | 2393278..2394060 | - | 783 | Protein_2358 | thiamine pyrophosphate-binding protein | - |
| L6477_RS12360 (BCM0074_2404) | 2394167..2394649 | + | 483 | WP_042512701.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| L6477_RS12365 (BCM0074_2405) | 2394817..2395554 | + | 738 | WP_042512700.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| L6477_RS12370 (BCM0074_2406) | 2395743..2396480 | + | 738 | WP_061681849.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| L6477_RS12375 (BCM0074_2407) | 2396593..2396718 | + | 126 | WP_000588936.1 | hypothetical protein | Antitoxin |
| L6477_RS12380 (BCM0074_2408) | 2396795..2396971 | + | 177 | WP_061681843.1 | stage II sporulation protein SB | - |
| L6477_RS12385 (BCM0074_2409) | 2397008..2397289 | - | 282 | WP_061681841.1 | hypothetical protein | - |
| L6477_RS12390 (BCM0074_2411) | 2397722..2397898 | + | 177 | WP_042512697.1 | stage II sporulation protein SB | - |
| L6477_RS12395 (BCM0074_2412) | 2398042..2399511 | + | 1470 | WP_236797900.1 | beta-Ala-His dipeptidase | - |
| L6477_RS12400 (BCM0074_2413) | 2400093..2400563 | - | 471 | WP_000670597.1 | DUF5065 family protein | - |
| L6477_RS12405 (BCM0074_2414) | 2400767..2401349 | + | 583 | Protein_2368 | SGNH/GDSL hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28372.17 Da Isoelectric Point: 9.3008
>T36636 WP_061681849.1 NZ_AP022886:2395743-2396480 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTKFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTKFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T36636 NZ_AP022886:2395743-2396480 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATTGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACAAAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAAGAATTAAATACAAAGTTTCGCGGTATCCGTTCTCAATTTAGTACCATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATTGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACAAAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAAGAATTAAATACAAAGTTTCGCGGTATCCGTTCTCAATTTAGTACCATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4888.29 Da Isoelectric Point: 3.9798
>AT36636 WP_000588936.1 NZ_AP022886:2396593-2396718 [Bacillus cereus]
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK
Download Length: 126 bp
>AT36636 NZ_AP022886:2396593-2396718 [Bacillus cereus]
GTGATAAAAGAGAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA
GTGATAAAAGAGAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|