Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2357403..2358378 Replicon chromosome
Accession NZ_AP022877
Organism Bacillus cereus strain MRY14-0060

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag L6481_RS12075 Protein ID WP_236807443.1
Coordinates 2357403..2358140 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag L6481_RS12080 Protein ID WP_061530834.1
Coordinates 2358253..2358378 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6481_RS12050 (BCM0060_2338) 2352949..2353356 + 408 WP_000072479.1 VOC family protein -
L6481_RS12055 (BCM0060_2339) 2353603..2353913 + 311 Protein_2301 hypothetical protein -
L6481_RS12060 (BCM0060_2340) 2354035..2355720 - 1686 WP_236807357.1 alpha-keto acid decarboxylase family protein -
L6481_RS12065 (BCM0060_2341) 2355827..2356309 + 483 WP_000191909.1 MarR family winged helix-turn-helix transcriptional regulator -
L6481_RS12070 (BCM0060_2342) 2356477..2357214 + 738 WP_236807358.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
L6481_RS12075 (BCM0060_2343) 2357403..2358140 + 738 WP_236807443.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
L6481_RS12080 (BCM0060_2344) 2358253..2358378 + 126 WP_061530834.1 hypothetical protein Antitoxin
L6481_RS12085 (BCM0060_2345) 2358455..2358631 + 177 WP_236807360.1 stage II sporulation protein SB -
L6481_RS12090 (BCM0060_2346) 2358668..2358949 - 282 WP_001041554.1 hypothetical protein -
L6481_RS12095 (BCM0060_2348) 2359240..2359468 - 229 Protein_2309 hypothetical protein -
L6481_RS29625 (BCM0060_2349) 2359596..2359724 + 129 WP_272884242.1 hypothetical protein -
L6481_RS12100 (BCM0060_2350) 2359801..2359977 + 177 WP_078418321.1 stage II sporulation protein SB -
L6481_RS12105 (BCM0060_2351) 2360121..2361590 + 1470 WP_236807363.1 beta-Ala-His dipeptidase -
L6481_RS12110 (BCM0060_2352) 2362172..2362642 - 471 WP_236804483.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28374.06 Da        Isoelectric Point: 7.3119

>T36634 WP_236807443.1 NZ_AP022877:2357403-2358140 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTDFRGIRSQFSTIIPLEYIEQLNEQRAVQVENIGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T36634 NZ_AP022877:2357403-2358140 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAGACTTTCGTGGTATCCGTTCTCAATTTAGTACTATCATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATATCGGAATTATTCCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4874.26 Da        Isoelectric Point: 3.9652

>AT36634 WP_061530834.1 NZ_AP022877:2358253-2358378 [Bacillus cereus]
VIKDNNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK

Download         Length: 126 bp

>AT36634 NZ_AP022877:2358253-2358378 [Bacillus cereus]
GTGATAAAAGATAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References