36630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 1956168..1957870 Replicon chromosome
Accession NZ_AP022873
Organism Dissulfurispira thermophila strain T55J

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag JTV28_RS10085 Protein ID WP_203472218.1
Coordinates 1957241..1957870 (-) Length 210 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag JTV28_RS10080 Protein ID WP_203472217.1
Coordinates 1956168..1957244 (-) Length 359 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTV28_RS10035 1951389..1951610 - 222 WP_203472209.1 type II toxin-antitoxin system HicB family antitoxin -
JTV28_RS10040 1951985..1952437 + 453 WP_203472210.1 DNA-binding protein -
JTV28_RS10045 1952490..1952888 + 399 WP_203472211.1 tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO -
JTV28_RS10050 1952895..1953662 + 768 WP_207105941.1 ATP-binding cassette domain-containing protein -
JTV28_RS10055 1953717..1954073 - 357 WP_203472212.1 DUF5615 family PIN-like protein -
JTV28_RS10060 1954063..1954296 - 234 WP_203472213.1 DUF433 domain-containing protein -
JTV28_RS10065 1954662..1955129 - 468 WP_203472214.1 DUF3368 domain-containing protein -
JTV28_RS10070 1955133..1955396 - 264 WP_203472215.1 UPF0175 family protein -
JTV28_RS10075 1955680..1956126 - 447 WP_203472216.1 DNA-binding protein -
JTV28_RS10080 1956168..1957244 - 1077 WP_203472217.1 macro domain-containing protein Antitoxin
JTV28_RS10085 1957241..1957870 - 630 WP_203472218.1 DUF4433 domain-containing protein Toxin
JTV28_RS10090 1957867..1961259 - 3393 WP_203472219.1 Eco57I restriction-modification methylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(7-207)

Antitoxin

Macro domain

(18-132)


Sequences

Toxin        


Download         Length: 210 a.a.        Molecular weight: 24655.43 Da        Isoelectric Point: 7.7730

>T36630 WP_203472218.1 NZ_AP022873:c1957870-1957241 [Dissulfurispira thermophila]
MNSTFIYRITHYRNLPFILQNGIHCQNSNINDPNFIQIGFPSLIDKRNERQVPIEPSGTLADYVPFYFTVRSPMLYVIAM
GNDPEVIKTPQEDIIYIVSSVEKLEGMKIKYVFTNRHAKLDYAQFYNKYADLKKLNWDIIESNKWGRQYGTERKEIKQAE
CLVYKHLPVTAIMGIGCKTEKMYNIINDMIERPSQDFFVTIKPEWYFEP

Download         Length: 630 bp

>T36630 NZ_AP022873:c1957870-1957241 [Dissulfurispira thermophila]
ATGAATTCAACCTTTATATATAGGATCACCCATTACAGAAATCTCCCTTTTATACTGCAAAACGGCATTCATTGTCAGAA
TTCTAATATTAATGACCCTAATTTCATACAAATTGGCTTTCCGTCGCTTATAGATAAAAGGAATGAACGGCAAGTGCCTA
TAGAGCCTTCCGGTACCCTTGCCGATTATGTGCCATTTTATTTTACTGTAAGGTCTCCTATGCTCTATGTTATAGCAATG
GGCAATGACCCAGAGGTTATAAAGACCCCGCAAGAGGATATAATTTATATAGTGAGCAGTGTTGAAAAGCTGGAAGGGAT
GAAGATTAAATATGTCTTTACTAATAGACATGCGAAGTTGGATTATGCCCAATTTTATAACAAATATGCAGACCTTAAGA
AACTCAATTGGGATATAATTGAAAGTAATAAATGGGGCAGACAATATGGAACTGAAAGGAAAGAAATTAAACAGGCAGAA
TGTCTTGTTTATAAACACTTGCCTGTGACAGCAATTATGGGTATAGGCTGTAAGACAGAAAAGATGTATAATATAATAAA
CGATATGATAGAGAGGCCAAGCCAGGATTTTTTTGTCACGATAAAACCAGAATGGTATTTTGAGCCATGA

Antitoxin


Download         Length: 359 a.a.        Molecular weight: 41833.08 Da        Isoelectric Point: 9.5693

>AT36630 WP_203472217.1 NZ_AP022873:c1957244-1956168 [Dissulfurispira thermophila]
MIKFIKGNIFESNAEALVNSVNTVGVMGKGIALQFKERFPENYRLYKKTCEEGRVTIGKMFVTSTNSLINPRWIINFPTK
KHWMHRSSYGFIEAGLDDLIKVIKDLNIKSIAIPPIGAGQGGLKWEKVKRIIEDKLGELDIEILVYEPDSINLMPISTNA
KLTKQRAMLLYLVELYRVLGYEITLLEIQKVAYFLQRLGQADLKLQFKKYYYGPYAHNLQHLLHHLRGSYLLTEKPILDS
RPYDNIYLNNEKLAEIKDFIDKYCSDTEIQRIEIISKIIEGFESPFGLELLATVDWILFNDRENKIQTIEDFQKAILRWS
KRKYDVFKKELIEIAFKRLMQFKEKLYPLNKLPILAPL

Download         Length: 1077 bp

>AT36630 NZ_AP022873:c1957244-1956168 [Dissulfurispira thermophila]
ATGATTAAATTTATCAAAGGAAATATCTTTGAAAGCAACGCCGAAGCACTGGTGAATTCTGTAAATACTGTTGGTGTTAT
GGGTAAGGGGATCGCCCTACAGTTCAAAGAGAGGTTCCCTGAGAATTACAGACTCTATAAAAAGACATGCGAAGAAGGCA
GGGTTACTATTGGAAAGATGTTTGTTACATCAACAAACAGCCTTATTAATCCCAGATGGATCATTAACTTCCCTACAAAG
AAACACTGGATGCATCGCTCAAGTTACGGATTTATAGAGGCAGGACTTGATGATTTGATTAAGGTTATCAAAGACTTGAA
CATAAAATCCATAGCTATCCCGCCCATTGGAGCAGGTCAGGGTGGGTTGAAGTGGGAAAAGGTCAAAAGAATTATTGAGG
ACAAACTCGGAGAATTGGATATAGAGATTCTTGTCTATGAGCCTGATAGTATAAATCTGATGCCCATATCAACAAATGCT
AAGCTAACCAAACAAAGGGCGATGCTCCTTTATCTGGTTGAATTGTATAGAGTCCTTGGTTATGAAATTACACTCCTTGA
GATACAAAAAGTTGCCTATTTTCTCCAGAGACTCGGACAAGCAGACCTGAAATTGCAATTCAAAAAATATTATTATGGTC
CATATGCCCACAATCTCCAGCATTTATTACATCACCTGAGGGGCTCATATCTCCTTACGGAGAAACCAATTCTTGATAGC
AGGCCCTACGATAATATATATCTGAATAATGAAAAACTTGCTGAAATCAAAGACTTTATAGATAAATACTGCTCAGACAC
AGAAATCCAGAGAATTGAAATAATTTCAAAGATTATAGAAGGATTTGAATCACCTTTCGGGCTTGAATTACTTGCAACTG
TTGACTGGATATTATTTAACGACCGCGAAAATAAGATTCAGACCATTGAAGACTTCCAGAAGGCTATCCTCAGATGGAGT
AAAAGGAAATACGATGTTTTTAAAAAAGAGTTGATAGAAATAGCCTTCAAACGTCTCATGCAGTTCAAAGAGAAACTCTA
TCCACTTAATAAACTTCCTATTCTAGCCCCTCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References