Detailed information of TA system TA036626

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 4438661..4439335
• Replicon: chromosome
• Accession: NZ_AP022871
• Organism: Phytohabitans suffuscus strain NBRC 105367

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: Psuf_RS19440
• Protein ID: WP_173158505.1
• Coordinates: 4438916..4439335 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: Psuf_RS19435
• Protein ID: WP_173158504.1
• Coordinates: 4438661..4438912 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Psuf_RS19410	4434214..4435194	-	981	WP_173166632.1	glycosyltransferase family 2 protein	-
Psuf_RS19415	4435228..4436346	+	1119	WP_173158501.1	alanine racemase	-
Psuf_RS19420	4436343..4437479	+	1137	WP_173158502.1	alpha/beta hydrolase	-
Psuf_RS19425	4437479..4437946	+	468	WP_173166634.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	-
Psuf_RS19430	4437943..4438623	+	681	WP_173158503.1	uracil-DNA glycosylase	-
Psuf_RS19435	4438661..4438912	+	252	WP_173158504.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Psuf_RS19440	4438916..4439335	+	420	WP_173158505.1	type II toxin-antitoxin system VapC family toxin	Toxin
Psuf_RS19445	4439401..4440072	+	672	WP_173158506.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	-
Psuf_RS19450	4440069..4440512	+	444	WP_173158507.1	ribosomal protein S18-alanine N-acetyltransferase	-
Psuf_RS19455	4440505..4441548	+	1044	WP_173158508.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	-
Psuf_RS19460	4441560..4441814	+	255	WP_173166636.1	hypothetical protein	-
Psuf_RS19465	4441844..4443616	-	1773	WP_173158509.1	substrate-binding and VWA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-65)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15151.34 Da
• Isoelectric Point: 7.2061

>T36626 WP_173158505.1 NZ_AP022871:4438916-4439335 [Phytohabitans suffuscus]
VGFLLDTNVVSELRKARPDPNVLAWHARNANADVFISVLVVGEIRRGIEGIRNRDPRQADALDAWLTGLVATYRDRVLPV
TAEVSDEWGRLAIAQPPPVIDGLMAATARVHQLTLVTRNVADVARTGVRVVNPFEPATA

Nucleotide

• Length: 420 bp

>T36626 NZ_AP022871:4438916-4439335 [Phytohabitans suffuscus]
GTGGGCTTCCTGCTGGACACCAACGTCGTTTCCGAGCTCCGCAAGGCCAGACCAGATCCCAACGTCCTGGCCTGGCACGC
GCGAAACGCGAACGCGGACGTGTTCATCAGCGTCCTGGTGGTCGGCGAGATCCGGCGCGGCATCGAAGGTATCCGCAATC
GTGATCCGCGGCAGGCGGATGCGCTCGACGCTTGGCTGACCGGGCTCGTCGCCACCTACCGCGACCGGGTGTTGCCGGTG
ACGGCGGAGGTCTCGGACGAGTGGGGGCGGCTCGCGATAGCCCAGCCTCCGCCGGTGATCGACGGGCTGATGGCGGCGAC
CGCGCGGGTGCACCAGCTCACCCTGGTCACCCGCAACGTGGCTGACGTCGCCCGGACGGGTGTTCGCGTGGTCAACCCGT
TCGAGCCGGCGACCGCGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9542.73 Da
• Isoelectric Point: 4.5822

>AT36626 WP_173158504.1 NZ_AP022871:4438661-4438912 [Phytohabitans suffuscus]
MRWQVQEAKQRFSEVLRAAESGEPQIVTKHGEEIAVVIDIAEYRRLRGEAVGFMDYLRAGPHLDDDLPIERPRDEPREID
LAG

Nucleotide

• Length: 252 bp

>AT36626 NZ_AP022871:4438661-4438912 [Phytohabitans suffuscus]
ATGCGCTGGCAGGTCCAGGAGGCGAAGCAGCGGTTCAGCGAGGTGCTCCGCGCGGCGGAGTCCGGCGAGCCGCAGATCGT
CACCAAGCACGGCGAGGAGATCGCCGTGGTCATCGACATCGCGGAGTACCGGCGCCTGCGGGGCGAGGCCGTCGGCTTCA
TGGACTACCTTCGCGCCGGCCCCCATCTCGACGATGACCTGCCGATCGAGCGCCCGCGCGACGAGCCGCGCGAGATCGAC
CTGGCCGGCTGA