Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 3711497..3711999 Replicon chromosome
Accession NZ_AP022869
Organism Halomonas meridiana strain Eplume2

Toxin (Protein)


Gene name yoeB Uniprot ID M7CQI7
Locus tag HMEPL2_RS17600 Protein ID WP_008938367.1
Coordinates 3711497..3711751 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A510J541
Locus tag HMEPL2_RS17605 Protein ID WP_044627927.1
Coordinates 3711748..3711999 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMEPL2_RS19590 3706683..3707282 + 600 WP_197746092.1 hypothetical protein -
HMEPL2_RS19595 3707326..3707577 + 252 WP_197746093.1 hypothetical protein -
HMEPL2_RS17555 3708100..3708393 + 294 WP_074210915.1 BrnT family toxin -
HMEPL2_RS17560 3708371..3708595 + 225 WP_074210914.1 BrnA antitoxin family protein -
HMEPL2_RS17565 3708750..3709022 + 273 WP_054640921.1 ribbon-helix-helix protein, CopG family -
HMEPL2_RS17570 3709019..3709300 + 282 WP_054640922.1 type II toxin-antitoxin system RelE/ParE family toxin -
HMEPL2_RS17575 3709434..3709736 + 303 WP_054640923.1 hypothetical protein -
HMEPL2_RS17580 3710237..3710551 - 315 WP_044630801.1 type II toxin-antitoxin system RelE/ParE family toxin -
HMEPL2_RS17585 3710554..3710790 - 237 WP_044630802.1 addiction module protein -
HMEPL2_RS17590 3710996..3711238 + 243 WP_044627930.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HMEPL2_RS17595 3711235..3711489 + 255 WP_172515574.1 Txe/YoeB family addiction module toxin -
HMEPL2_RS17600 3711497..3711751 - 255 WP_008938367.1 Txe/YoeB family addiction module toxin Toxin
HMEPL2_RS17605 3711748..3711999 - 252 WP_044627927.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HMEPL2_RS17610 3712056..3712301 - 246 WP_074211298.1 IS66 family insertion sequence element accessory protein TnpB -
HMEPL2_RS17615 3712340..3713749 + 1410 WP_062373493.1 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase -
HMEPL2_RS17620 3713760..3714110 - 351 WP_062359339.1 hypothetical protein -
HMEPL2_RS17625 3714123..3715055 - 933 WP_062359338.1 lysophospholipid acyltransferase family protein -
HMEPL2_RS17630 3715059..3715454 - 396 WP_044627923.1 DUF4870 domain-containing protein -
HMEPL2_RS17635 3715575..3715958 - 384 WP_044627922.1 VOC family protein -
HMEPL2_RS17640 3715999..3716652 + 654 WP_172515575.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3686410..3711999 25589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10236.82 Da        Isoelectric Point: 9.8162

>T36618 WP_008938367.1 NZ_AP022869:c3711751-3711497 [Halomonas meridiana]
MKLIFSENAWEDYLYWQKTDKKILNRINKLIKETKREPFEGVGKPEPLKHSLAGYWSRRINEEHRIVYKVTDDALLIAQL
RYHY

Download         Length: 255 bp

>T36618 NZ_AP022869:c3711751-3711497 [Halomonas meridiana]
ATGAAACTCATCTTCTCCGAGAACGCCTGGGAAGACTATCTGTACTGGCAGAAAACCGACAAAAAGATACTTAACCGAAT
CAACAAACTGATCAAAGAGACCAAACGAGAACCGTTCGAAGGTGTTGGCAAACCAGAGCCCCTCAAACACAGCCTCGCCG
GGTACTGGTCTCGCCGGATCAACGAAGAACACCGAATAGTTTACAAAGTCACGGATGACGCTTTGCTTATCGCCCAGCTC
CGGTATCACTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9296.52 Da        Isoelectric Point: 4.4750

>AT36618 WP_044627927.1 NZ_AP022869:c3711999-3711748 [Halomonas meridiana]
MDAISYTAARTNLAKTMEQVCEDHSPVIITRNKSQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE

Download         Length: 252 bp

>AT36618 NZ_AP022869:c3711999-3711748 [Halomonas meridiana]
ATGGATGCCATTAGCTACACAGCCGCTAGAACCAATCTAGCAAAAACCATGGAGCAGGTCTGTGAAGACCATTCCCCTGT
GATCATCACCCGGAACAAGTCGCAGTCCGTGGTAATGATCTCCCTAGAGGACTACGAGGCGCTGCAAGAGACTGCATACC
TTCTGCGCGCACCAAAAAACGCACGGCGTTTGCTGGAATCCGTTGCCGAGCTGGAGCAAGGCGGTGGTCAAGAAAAGGAA
CTTCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7CQI7

Antitoxin

Source ID Structure
AlphaFold DB A0A510J541

References