Detailed information of TA system TA036612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-couple_hipB
• Location: 2227209..2227830
• Replicon: chromosome
• Accession: NZ_AP022869
• Organism: Halomonas meridiana strain Eplume2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HMEPL2_RS10485
• Protein ID: WP_172515034.1
• Coordinates: 2227209..2227424 (+)
• Length: 72 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1N6CYN2
• Locus tag: HMEPL2_RS10490
• Protein ID: WP_074211399.1
• Coordinates: 2227468..2227830 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMEPL2_RS10470	2223113..2224684	-	1572	WP_172515032.1	Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha	-
HMEPL2_RS10475	2224925..2225848	-	924	WP_172515033.1	LysR family transcriptional regulator	-
HMEPL2_RS10480	2226018..2226932	+	915	WP_172515712.1	agmatinase	-
HMEPL2_RS10485	2227209..2227424	+	216	WP_172515034.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HMEPL2_RS10490	2227468..2227830	+	363	WP_074211399.1	helix-turn-helix transcriptional regulator	Antitoxin
HMEPL2_RS10495	2227870..2228229	+	360	WP_197746067.1	glycosyltransferase	-
HMEPL2_RS10500	2228377..2229354	+	978	WP_172515035.1	TAXI family TRAP transporter solute-binding subunit	-
HMEPL2_RS10505	2229412..2231181	+	1770	WP_172515036.1	TRAP transporter fused permease subunit	-
HMEPL2_RS10510	2231208..2231753	-	546	WP_172515037.1	hypothetical protein	-
HMEPL2_RS10515	2231770..2231946	-	177	WP_172515038.1	fumarylacetoacetate hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (65-119)

Sequences

Toxin

Protein

• Length: 72 a.a.
• Molecular weight: 8203.59 Da
• Isoelectric Point: 11.4186

>T36612 WP_172515034.1 NZ_AP022869:2227209-2227424 [Halomonas meridiana]
MNTITYRKSALKVLQRMPRPESKRIQGKIKAYAEGPESQRNNMKALKGSKYIRLRVGDWRVIIDERGGVSQ

Nucleotide

• Length: 216 bp

>T36612 NZ_AP022869:2227209-2227424 [Halomonas meridiana]
ATGAACACGATCACTTACCGGAAAAGCGCGTTGAAGGTATTGCAGCGAATGCCACGGCCAGAGTCGAAGCGCATACAAGG
CAAGATCAAGGCCTACGCGGAAGGCCCAGAAAGCCAGCGCAATAATATGAAGGCGTTGAAAGGGAGCAAGTATATTCGTC
TGCGGGTAGGCGACTGGCGGGTGATCATCGACGAGCGCGGCGGTGTTTCTCAATAG

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 12943.70 Da
• Isoelectric Point: 4.1961

>AT36612 WP_074211399.1 NZ_AP022869:2227468-2227830 [Halomonas meridiana]
MSVPQIIQTPTGERLVVLPEQEYYALLARLEDQDDINAANAVVARGEESFPEAVVNTLLDGVVPVKVYREYRGLRAGELA
EKAGISQGYLSEIEAGKKSGSLSVLTRIAAALDVELSDLI

Nucleotide

• Length: 363 bp

>AT36612 NZ_AP022869:2227468-2227830 [Halomonas meridiana]
ATGAGCGTCCCTCAAATTATTCAAACGCCCACCGGCGAGCGGTTGGTGGTACTGCCTGAGCAGGAGTACTACGCCTTGCT
TGCTCGACTGGAAGACCAGGACGATATCAACGCTGCAAACGCGGTAGTGGCTCGCGGTGAAGAGTCGTTTCCAGAAGCGG
TTGTGAATACGCTGCTGGACGGTGTGGTACCCGTGAAAGTGTACCGTGAATACCGTGGCCTGCGTGCGGGAGAACTAGCG
GAAAAAGCAGGGATTAGCCAGGGATATCTTTCCGAAATAGAGGCAGGCAAAAAGAGCGGCTCGCTGAGCGTGCTAACCCG
TATTGCGGCTGCTTTAGATGTGGAGTTAAGCGACCTCATCTAG

Structures

Antitoxin

• AlphaFold DB: A0A1N6CYN2