Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1497437..1498122 Replicon chromosome
Accession NZ_AP022869
Organism Halomonas meridiana strain Eplume2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HMEPL2_RS07050 Protein ID WP_172514790.1
Coordinates 1497437..1497880 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HMEPL2_RS07055 Protein ID WP_172515693.1
Coordinates 1497880..1498122 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMEPL2_RS07040 1493334..1494113 - 780 WP_172514788.1 DUF4391 domain-containing protein -
HMEPL2_RS07045 1494110..1497376 - 3267 WP_197746141.1 DEAD/DEAH box helicase family protein -
HMEPL2_RS07050 1497437..1497880 - 444 WP_172514790.1 PIN domain-containing protein Toxin
HMEPL2_RS07055 1497880..1498122 - 243 WP_172515693.1 Arc family DNA-binding protein Antitoxin
HMEPL2_RS07060 1498592..1498813 + 222 WP_090538720.1 hypothetical protein -
HMEPL2_RS07065 1498810..1499562 + 753 WP_172514791.1 P-type conjugative transfer protein TrbJ -
HMEPL2_RS07070 1499573..1499779 + 207 WP_090538718.1 hypothetical protein -
HMEPL2_RS07075 1499776..1501287 + 1512 WP_172514792.1 P-type conjugative transfer protein TrbL -
HMEPL2_RS07080 1501277..1501471 + 195 WP_090538716.1 hypothetical protein -
HMEPL2_RS07085 1501997..1502761 - 765 WP_172514793.1 ABC transporter ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1487079..1512007 24928


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15783.51 Da        Isoelectric Point: 5.7287

>T36611 WP_172514790.1 NZ_AP022869:c1497880-1497437 [Halomonas meridiana]
MILLDISIISELLRNTPAPKVIEWMDAQPLETMYISATTMAELQLGMALVEDEDRRNKGLKDLEQRLPPLFIGRILPFDQ
SCIGAFGALVAKAIQRGTPLRESDAFVAAVAVTHGLVVASLHIDSFKALGVSSVSPLIVAKAGTAKS

Download         Length: 444 bp

>T36611 NZ_AP022869:c1497880-1497437 [Halomonas meridiana]
ATGATTCTGCTCGACATCAGCATCATCAGCGAGCTGCTGCGCAACACCCCTGCGCCAAAGGTCATCGAGTGGATGGATGC
CCAGCCGCTGGAAACGATGTATATCTCCGCAACCACCATGGCTGAACTGCAGCTGGGCATGGCGCTGGTTGAGGACGAGG
ATCGTCGTAACAAAGGGTTGAAAGACTTGGAACAGCGTCTGCCACCACTCTTCATCGGCAGGATCTTACCCTTTGATCAG
TCCTGCATCGGCGCTTTCGGGGCCTTGGTGGCCAAGGCCATCCAGCGCGGGACCCCATTGAGAGAGAGCGACGCCTTTGT
AGCCGCCGTTGCGGTTACCCATGGCCTGGTTGTTGCGTCGCTGCATATTGATTCATTCAAGGCGCTTGGGGTTAGCAGTG
TCAGCCCCTTGATAGTGGCCAAAGCGGGAACGGCCAAGAGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8504.89 Da        Isoelectric Point: 8.9117

>AT36611 WP_172515693.1 NZ_AP022869:c1498122-1497880 [Halomonas meridiana]
MAMLTVRNLPDEVHRALRVRAALHGHSMEAEAREILEAALAPEGRVKLGSLLADIGKQAKLTDKELASFGAARAGHPVGI

Download         Length: 243 bp

>AT36611 NZ_AP022869:c1498122-1497880 [Halomonas meridiana]
ATGGCCATGCTGACTGTTCGCAACCTTCCTGATGAGGTACACCGCGCCTTGCGCGTCCGTGCAGCTCTGCATGGGCACAG
CATGGAAGCCGAGGCACGCGAGATCCTGGAGGCTGCTTTAGCGCCCGAGGGGAGGGTCAAACTGGGCTCTCTGCTGGCCG
ACATAGGCAAGCAGGCCAAGCTGACCGATAAAGAACTTGCATCCTTTGGTGCGGCTCGCGCTGGGCACCCGGTTGGCATC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References