Detailed information of TA system TA036610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1367202..1367727
• Replicon: chromosome
• Accession: NZ_AP022869
• Organism: Halomonas meridiana strain Eplume2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HMEPL2_RS06450
• Protein ID: WP_089675540.1
• Coordinates: 1367202..1367486 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6F8XC30
• Locus tag: HMEPL2_RS06455
• Protein ID: WP_062372637.1
• Coordinates: 1367476..1367727 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMEPL2_RS06420	1362497..1363480	+	984	WP_062372649.1	putative zinc-binding metallopeptidase	-
HMEPL2_RS06425	1363506..1364399	-	894	WP_172514741.1	dihydrodipicolinate synthase family protein	-
HMEPL2_RS06430	1364455..1365207	-	753	WP_089675544.1	SDR family oxidoreductase	-
HMEPL2_RS06435	1365387..1366217	+	831	WP_089675543.1	AraC family transcriptional regulator	-
HMEPL2_RS06440	1366244..1366855	+	612	WP_089675542.1	LysE family transporter	-
HMEPL2_RS06445	1366839..1367159	-	321	WP_089675541.1	hypothetical protein	-
HMEPL2_RS06450	1367202..1367486	-	285	WP_089675540.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HMEPL2_RS06455	1367476..1367727	-	252	WP_062372637.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HMEPL2_RS06460	1367840..1368658	-	819	WP_172514742.1	tryptophan synthase subunit alpha	-
HMEPL2_RS06465	1368679..1369896	-	1218	WP_054641486.1	tryptophan synthase subunit beta	-
HMEPL2_RS06470	1370019..1370909	+	891	WP_172514743.1	LysR family transcriptional regulator	-
HMEPL2_RS06475	1370906..1371025	-	120	Protein_1266	VOC family protein	-
HMEPL2_RS06480	1371030..1371242	+	213	Protein_1267	glycerophosphodiester phosphodiesterase	-
HMEPL2_RS06485	1371261..1371893	-	633	WP_172514744.1	hypothetical protein	-
HMEPL2_RS06490	1371905..1372636	-	732	WP_172514745.1	oxygen-insensitive NADPH nitroreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11026.14 Da
• Isoelectric Point: 10.4966

>T36610 WP_089675540.1 NZ_AP022869:c1367486-1367202 [Halomonas meridiana]
MTYKLRFLPAALKEWEKLSPPVKQQFKKKLAERLETPRVPADKLSGFDACYKIKLRSVGYRLVYEVVDDELFIYVIAVGK
RDKGKVYASLKRRM

Nucleotide

• Length: 285 bp

>T36610 NZ_AP022869:c1367486-1367202 [Halomonas meridiana]
ATGACCTATAAGCTACGCTTTTTGCCCGCGGCCTTGAAAGAGTGGGAAAAGCTTAGCCCACCCGTCAAACAACAGTTCAA
AAAGAAGCTGGCTGAAAGGCTAGAAACCCCTCGTGTGCCTGCCGATAAACTCAGTGGTTTCGATGCCTGCTATAAAATAA
AGCTTCGAAGCGTAGGCTATCGTCTGGTCTATGAAGTAGTGGATGATGAACTGTTTATCTACGTTATTGCTGTGGGTAAG
CGTGACAAAGGCAAAGTCTACGCGTCGCTAAAGCGCCGGATGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9159.51 Da
• Isoelectric Point: 4.5659

>AT36610 WP_062372637.1 NZ_AP022869:c1367727-1367476 [Halomonas meridiana]
MHQVLANFSVSISELKKNPSALLSQASGAPIAVLNHNKPAAYLVPVETYEAMMEMLEDYELAKLVEERRADKDKAVTVSL
DDL

Nucleotide

• Length: 252 bp

>AT36610 NZ_AP022869:c1367727-1367476 [Halomonas meridiana]
ATGCACCAAGTATTAGCTAACTTTTCGGTCAGTATTTCTGAGCTAAAGAAAAACCCTTCGGCACTGCTGAGCCAGGCAAG
CGGTGCCCCCATTGCTGTGTTGAATCACAACAAGCCCGCCGCTTACCTTGTCCCTGTAGAAACTTATGAGGCGATGATGG
AGATGCTGGAAGACTACGAGCTGGCCAAGCTAGTGGAAGAGCGTCGCGCCGATAAAGACAAGGCCGTCACGGTATCACTG
GATGACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A6F8XC30