Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1361411..1361924 Replicon chromosome
Accession NZ_AP022869
Organism Halomonas meridiana strain Eplume2

Toxin (Protein)


Gene name relB Uniprot ID A0A6F8XC19
Locus tag HMEPL2_RS06405 Protein ID WP_062372655.1
Coordinates 1361411..1361677 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A6F8X962
Locus tag HMEPL2_RS06410 Protein ID WP_062372652.1
Coordinates 1361670..1361924 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMEPL2_RS06380 1357019..1357726 + 708 WP_172514738.1 autoinducer binding domain-containing protein -
HMEPL2_RS06385 1357910..1359103 + 1194 WP_172515689.1 MFS transporter -
HMEPL2_RS06390 1359153..1359560 + 408 Protein_1249 ATP-binding domain-containing protein -
HMEPL2_RS06395 1359608..1360525 - 918 WP_172514739.1 restriction endonuclease -
HMEPL2_RS06400 1360560..1361318 - 759 WP_172514740.1 carbon-nitrogen hydrolase family protein -
HMEPL2_RS06405 1361411..1361677 - 267 WP_062372655.1 Txe/YoeB family addiction module toxin Toxin
HMEPL2_RS06410 1361670..1361924 - 255 WP_062372652.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HMEPL2_RS06415 1362007..1362342 - 336 WP_062372795.1 PhnA domain-containing protein -
HMEPL2_RS06420 1362497..1363480 + 984 WP_062372649.1 putative zinc-binding metallopeptidase -
HMEPL2_RS06425 1363506..1364399 - 894 WP_172514741.1 dihydrodipicolinate synthase family protein -
HMEPL2_RS06430 1364455..1365207 - 753 WP_089675544.1 SDR family oxidoreductase -
HMEPL2_RS06435 1365387..1366217 + 831 WP_089675543.1 AraC family transcriptional regulator -
HMEPL2_RS06440 1366244..1366855 + 612 WP_089675542.1 LysE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10529.97 Da        Isoelectric Point: 9.0209

>T36609 WP_062372655.1 NZ_AP022869:c1361677-1361411 [Halomonas meridiana]
MSSQRLLCWTDESWNDYVYWQAQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDHHAIT
VISCRYHY

Download         Length: 267 bp

>T36609 NZ_AP022869:c1361677-1361411 [Halomonas meridiana]
ATGAGTAGTCAGCGACTGTTGTGTTGGACAGATGAATCTTGGAACGACTACGTCTATTGGCAAGCGCAGGATAAGAAAAC
CCTTAAGCGCATTAATAAGCTGATAAACGATGTAAAGCGCTCTCCCTTTGAAGGAATCGGCAAGCCAGAGCCCTTAAAAG
AAAACCTAGCGGGCTTTTGGTCTCGACGTATAGACGATACTAATCGGCTTGTTTATGCAGTCGATCACCACGCGATCACT
GTCATTTCTTGCCGCTATCACTATTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9413.60 Da        Isoelectric Point: 5.0622

>AT36609 WP_062372652.1 NZ_AP022869:c1361924-1361670 [Halomonas meridiana]
MKIVSFTEARNGLKAVLDGVVNDADTTVITRRDAEDAVVMSLDYYNSLMETVHLLRSPKNAEHLNRSIAQYRAGQTSARE
LMDE

Download         Length: 255 bp

>AT36609 NZ_AP022869:c1361924-1361670 [Halomonas meridiana]
ATGAAAATTGTGTCTTTTACAGAAGCGAGGAATGGCTTAAAAGCCGTGCTGGATGGCGTCGTTAATGATGCGGATACCAC
CGTGATCACGCGCAGGGATGCTGAAGATGCCGTTGTGATGTCGCTGGATTATTACAATAGCCTAATGGAAACAGTGCACC
TGCTTCGTTCGCCTAAAAATGCTGAACACCTTAACCGCTCAATAGCGCAATATCGTGCTGGCCAAACAAGCGCACGAGAG
TTAATGGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6F8XC19

Antitoxin

Source ID Structure
AlphaFold DB A0A6F8X962

References