Detailed information of TA system TA036608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1270369..1270967
• Replicon: chromosome
• Accession: NZ_AP022869
• Organism: Halomonas meridiana strain Eplume2

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: HMEPL2_RS05945
• Protein ID: WP_172514713.1
• Coordinates: 1270369..1270668 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: A0A455V626
• Locus tag: HMEPL2_RS05950
• Protein ID: WP_054641079.1
• Coordinates: 1270665..1270967 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMEPL2_RS05930	1266180..1268744	-	2565	WP_172514711.1	ABC transporter permease	-
HMEPL2_RS05935	1268737..1269447	-	711	WP_082051502.1	ABC transporter ATP-binding protein	-
HMEPL2_RS05940	1269545..1270282	+	738	WP_172514712.1	arylesterase	-
HMEPL2_RS05945	1270369..1270668	+	300	WP_172514713.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HMEPL2_RS05950	1270665..1270967	+	303	WP_054641079.1	putative addiction module antidote protein	Antitoxin
HMEPL2_RS05955	1271173..1272060	-	888	WP_172514714.1	DMT family transporter	-
HMEPL2_RS05960	1272057..1272326	-	270	WP_172514715.1	SelT/SelW/SelH family protein	-
HMEPL2_RS05965	1272484..1273797	+	1314	Protein_1167	MFS transporter	-
HMEPL2_RS05970	1273984..1274421	+	438	WP_062361625.1	PAS domain S-box protein	-
HMEPL2_RS05975	1274584..1274796	+	213	WP_172514716.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (28-91)

Antitoxin

• Uncharacterized protein HI1420 (5-91)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11248.81 Da
• Isoelectric Point: 9.9573

>T36608 WP_172514713.1 NZ_AP022869:1270369-1270668 [Halomonas meridiana]
MLAIKQTDTYRRWERKLRDSHAKALIAARIFRLANGLTGDVKPVGQGISELRIHHGPGYRVYFKQRGNELVILLCGGDKS
TQQNDIDTAQRLAAEWEES

Nucleotide

• Length: 300 bp

>T36608 NZ_AP022869:1270369-1270668 [Halomonas meridiana]
ATGCTCGCTATTAAACAAACCGACACTTACCGACGGTGGGAACGTAAGCTCCGCGATTCGCACGCCAAAGCACTGATTGC
CGCCCGTATTTTCAGGCTGGCCAACGGATTGACTGGCGATGTAAAACCCGTTGGTCAAGGCATCAGTGAACTGCGTATTC
ATCATGGCCCAGGATATCGTGTCTATTTTAAACAACGCGGTAATGAGCTTGTCATCCTGTTGTGTGGTGGCGATAAAAGC
ACTCAGCAAAACGATATCGATACAGCGCAGCGTCTGGCAGCAGAATGGGAGGAATCATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10839.31 Da
• Isoelectric Point: 4.3766

>AT36608 WP_054641079.1 NZ_AP022869:1270665-1270967 [Halomonas meridiana]
MSDKIYDYDPAAALENDEAIALFLADALETGDATYVAKAMGIVARAKGMTELARETGLSREQLYRSFSEQGNPTLKTMLA
VMRALGMDLTAKPHQEEPAA

Nucleotide

• Length: 303 bp

>AT36608 NZ_AP022869:1270665-1270967 [Halomonas meridiana]
ATGAGCGATAAGATTTACGACTATGACCCAGCAGCAGCCTTAGAGAACGATGAAGCCATCGCGCTCTTTCTCGCTGATGC
GCTGGAAACCGGAGATGCCACTTATGTTGCTAAAGCGATGGGTATCGTAGCGCGCGCTAAAGGAATGACAGAGCTTGCTC
GCGAAACCGGCCTCTCCCGTGAGCAGCTCTATCGTTCGTTCAGCGAGCAAGGCAACCCAACGCTGAAGACGATGTTGGCC
GTCATGCGTGCACTGGGTATGGACTTGACGGCAAAACCACACCAAGAAGAACCAGCAGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A455V626