Detailed information of TA system TA036607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 219795..220327
• Replicon: chromosome
• Accession: NZ_AP022869
• Organism: Halomonas meridiana strain Eplume2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HMEPL2_RS01030
• Protein ID: WP_172514393.1
• Coordinates: 219795..220088 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A4U3C875
• Locus tag: HMEPL2_RS01035
• Protein ID: WP_044630393.1
• Coordinates: 220088..220327 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMEPL2_RS00985	214889..215203	+	315	WP_054641851.1	hypothetical protein	-
HMEPL2_RS00990	215196..215495	+	300	WP_062373489.1	helix-turn-helix domain-containing protein	-
HMEPL2_RS19520	215562..216119	-	558	WP_197746116.1	BrnT family toxin	-
HMEPL2_RS01000	216279..216518	+	240	WP_172514388.1	hypothetical protein	-
HMEPL2_RS01005	216530..217114	+	585	WP_172514389.1	hypothetical protein	-
HMEPL2_RS01010	217104..217328	+	225	WP_172514390.1	hypothetical protein	-
HMEPL2_RS01015	217318..219009	+	1692	WP_172514391.1	DUF2326 domain-containing protein	-
HMEPL2_RS01020	219105..219659	+	555	WP_172514392.1	sugar O-acetyltransferase	-
HMEPL2_RS01025	219671..219787	+	117	WP_172515662.1	DUF3265 domain-containing protein	-
HMEPL2_RS01030	219795..220088	-	294	WP_172514393.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HMEPL2_RS01035	220088..220327	-	240	WP_044630393.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HMEPL2_RS01040	220511..220905	+	395	Protein_200	AAA family ATPase	-
HMEPL2_RS01045	220900..221163	-	264	Protein_201	DEAD/DEAH box helicase	-
HMEPL2_RS01050	221232..221522	+	291	WP_172514394.1	IS66 family insertion sequence element accessory protein TnpB	-
HMEPL2_RS01055	221519..221782	+	264	WP_172514395.1	IS66 family insertion sequence element accessory protein TnpB	-
HMEPL2_RS01060	221890..223527	+	1638	WP_172514396.1	IS66 family transposase	-
HMEPL2_RS01065	223517..223786	+	270	WP_062375866.1	hypothetical protein	-
HMEPL2_RS01070	223946..224368	+	423	WP_044630396.1	hypothetical protein	-
HMEPL2_RS01075	224379..224849	+	471	WP_172514397.1	DUF1456 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	212083..220327	8244
	-	flank	IS/Tn	-	-	221519..221782	263

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11306.97 Da
• Isoelectric Point: 10.4460

>T36607 WP_172514393.1 NZ_AP022869:c220088-219795 [Halomonas meridiana]
MRPYLLTASARKDVVEIGRFTTEKWGKRQRDTYLRQLDDAFKLLARQPDIGRDTGDIKPGYKKFSQGSHVIFYRAGTESR
IVVIRILHNSMDVEQHL

Nucleotide

• Length: 294 bp

>T36607 NZ_AP022869:c220088-219795 [Halomonas meridiana]
ATGCGTCCATACCTGCTCACTGCCTCTGCCCGAAAAGACGTTGTCGAGATAGGCCGCTTCACCACCGAAAAGTGGGGAAA
GCGCCAACGCGATACGTACCTCAGGCAGCTTGACGATGCTTTCAAGCTGCTCGCTCGCCAACCTGATATTGGCCGCGATA
CGGGTGACATAAAACCAGGGTACAAAAAGTTCAGTCAGGGCAGTCATGTTATCTTTTACAGAGCCGGTACGGAATCCAGG
ATCGTTGTCATCCGAATTCTCCACAACAGTATGGATGTGGAGCAGCATCTTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8875.88 Da
• Isoelectric Point: 4.3041

>AT36607 WP_044630393.1 NZ_AP022869:c220327-220088 [Halomonas meridiana]
MARNTSITLGPHFDEFIAIQVEKGRYGSVSEVVRAGLRLLEETESKLERLQRLLDEGEQSGIAEYSLESVITELDNEAH

Nucleotide

• Length: 240 bp

>AT36607 NZ_AP022869:c220327-220088 [Halomonas meridiana]
ATGGCTAGAAATACCAGCATTACACTCGGCCCCCACTTTGATGAGTTTATAGCCATTCAGGTTGAAAAGGGCCGCTATGG
CTCGGTGAGCGAGGTGGTACGTGCCGGACTGCGTCTGCTTGAAGAAACGGAAAGTAAGCTTGAACGGCTCCAACGCCTTC
TGGATGAAGGCGAACAGAGCGGAATCGCAGAGTATTCCCTTGAAAGCGTTATTACAGAACTGGACAACGAAGCTCACTGA

Structures

Antitoxin

• AlphaFold DB: A0A4U3C875