Detailed information of TA system TA036606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 1400108..1400961
• Replicon: chromosome
• Accession: NZ_AP022868
• Organism: Bifidobacterium longum strain Jih1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V6XWY1
• Locus tag: BLJIH1_RS06045
• Protein ID: WP_007054468.1
• Coordinates: 1400108..1400599 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V6XX41
• Locus tag: BLJIH1_RS06050
• Protein ID: WP_008783109.1
• Coordinates: 1400599..1400961 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLJIH1_RS06025	1395180..1396412	+	1233	WP_007056207.1	sensor histidine kinase	-
BLJIH1_RS06030	1396447..1397172	+	726	WP_007056206.1	response regulator transcription factor	-
BLJIH1_RS06035	1397212..1397853	+	642	WP_007052627.1	GNAT family N-acetyltransferase	-
BLJIH1_RS06040	1397943..1400048	+	2106	WP_172476713.1	DUF262 domain-containing protein	-
BLJIH1_RS06045	1400108..1400599	-	492	WP_007054468.1	PIN domain-containing protein	Toxin
BLJIH1_RS06050	1400599..1400961	-	363	WP_008783109.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BLJIH1_RS06055	1401107..1403806	-	2700	WP_172476714.1	aconitate hydratase AcnA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-141)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-53)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18328.91 Da
• Isoelectric Point: 4.5590

>T36606 WP_007054468.1 NZ_AP022868:c1400599-1400108 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNITLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Nucleotide

• Length: 492 bp

>T36606 NZ_AP022868:c1400599-1400108 [Bifidobacterium longum]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAACGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACATTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAACTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCACTGGAATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13974.03 Da
• Isoelectric Point: 5.0733

>AT36606 WP_008783109.1 NZ_AP022868:c1400961-1400599 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Nucleotide

• Length: 363 bp

>AT36606 NZ_AP022868:c1400961-1400599 [Bifidobacterium longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCCTTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA

Structures

Toxin

• AlphaFold DB: V6XWY1

Antitoxin

• AlphaFold DB: V6XX41