Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 847296..847816 Replicon chromosome
Accession NZ_AP022868
Organism Bifidobacterium longum strain Jih1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4R0S5R9
Locus tag BLJIH1_RS03605 Protein ID WP_065445101.1
Coordinates 847296..847550 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID I3B069
Locus tag BLJIH1_RS03610 Protein ID WP_007051980.1
Coordinates 847550..847816 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLJIH1_RS03580 842967..844643 - 1677 WP_007053508.1 ATP-binding protein -
BLJIH1_RS03585 844732..844977 - 246 WP_007053507.1 hypothetical protein -
BLJIH1_RS03590 845216..845764 + 549 WP_131220502.1 hypothetical protein -
BLJIH1_RS03595 845775..846155 + 381 WP_065445105.1 hypothetical protein -
BLJIH1_RS03600 846238..847302 + 1065 WP_131223115.1 hypothetical protein -
BLJIH1_RS03605 847296..847550 - 255 WP_065445101.1 Txe/YoeB family addiction module toxin Toxin
BLJIH1_RS03610 847550..847816 - 267 WP_007051980.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BLJIH1_RS03615 847998..848378 + 381 WP_058062621.1 hypothetical protein -
BLJIH1_RS03620 848401..848823 + 423 WP_065436687.1 hypothetical protein -
BLJIH1_RS03625 849145..849420 - 276 WP_060868196.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 827155..874028 46873


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-76)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9962.38 Da        Isoelectric Point: 8.4890

>T36605 WP_065445101.1 NZ_AP022868:c847550-847296 [Bifidobacterium longum]
MLLCWTDDAWADYLYWQSQDRRTLKRVNTLIRDMQRTPFEGIGKPEPLKWGLSGAWSRRIDSANRIIYTVADDRLCILSA
KDHY

Download         Length: 255 bp

>T36605 NZ_AP022868:c847550-847296 [Bifidobacterium longum]
ATGCTGCTCTGCTGGACCGATGACGCCTGGGCCGACTACCTGTACTGGCAATCCCAGGACCGCAGGACCCTCAAACGCGT
CAACACGCTCATCCGGGATATGCAGCGTACCCCGTTCGAAGGCATCGGCAAGCCCGAACCCCTCAAATGGGGCCTGTCCG
GCGCATGGTCGCGGCGCATCGACTCAGCCAACCGCATCATCTACACCGTCGCCGACGACAGGCTCTGCATCCTCTCCGCG
AAGGACCACTACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9922.13 Da        Isoelectric Point: 4.3407

>AT36605 WP_007051980.1 NZ_AP022868:c847816-847550 [Bifidobacterium longum]
MTQAVAYSNFRANLKTYMRRVNEDADTLLVTNADPEDNVVVMSADDYDSLMETLRVYQNPYLSDKVMRGMAQVRQGQTMA
HDLVEAGA

Download         Length: 267 bp

>AT36605 NZ_AP022868:c847816-847550 [Bifidobacterium longum]
ATGACACAGGCCGTGGCCTACAGCAATTTCAGGGCGAATCTCAAGACCTACATGCGCAGGGTCAACGAGGACGCCGACAC
CCTTCTCGTGACCAACGCGGACCCGGAGGACAACGTGGTCGTCATGAGCGCCGACGACTACGATTCGCTCATGGAGACGC
TGCGCGTCTACCAGAACCCGTATCTGAGCGATAAGGTGATGCGCGGCATGGCGCAGGTCCGGCAGGGCCAGACGATGGCC
CACGACCTTGTCGAAGCGGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0S5R9

Antitoxin

Source ID Structure
AlphaFold DB I3B069

References