Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1713847..1714436 Replicon chromosome
Accession NZ_AP022867
Organism Haemophilus influenzae strain 2018-Y40

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag HIY_RS08715 Protein ID WP_005653200.1
Coordinates 1714188..1714436 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag HIY_RS08710 Protein ID WP_005653201.1
Coordinates 1713847..1714191 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIY_RS08695 1709070..1710464 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
HIY_RS08700 1710508..1711122 + 615 WP_005657019.1 riboflavin synthase -
HIY_RS08705 1711194..1713803 - 2610 WP_005657022.1 aminopeptidase N -
HIY_RS08710 1713847..1714191 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HIY_RS08715 1714188..1714436 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
HIY_RS08720 1714855..1715349 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
HIY_RS08725 1715419..1716507 + 1089 WP_005657028.1 5-(carboxyamino)imidazole ribonucleotide synthase -
HIY_RS08730 1716647..1717837 + 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
HIY_RS08735 1718059..1718676 - 618 WP_005657032.1 energy-coupling factor ABC transporter ATP-binding protein -
HIY_RS08740 1718678..1719310 - 633 WP_005657034.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T36604 WP_005653200.1 NZ_AP022867:c1714436-1714188 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T36604 NZ_AP022867:c1714436-1714188 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCCCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT36604 WP_005653201.1 NZ_AP022867:c1714191-1713847 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT36604 NZ_AP022867:c1714191-1713847 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References