Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1642077..1642721 | Replicon | chromosome |
| Accession | NZ_AP022867 | ||
| Organism | Haemophilus influenzae strain 2018-Y40 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q4QKY0 |
| Locus tag | HIY_RS08340 | Protein ID | WP_005643265.1 |
| Coordinates | 1642536..1642721 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q4QKX9 |
| Locus tag | HIY_RS08335 | Protein ID | WP_005692602.1 |
| Coordinates | 1642077..1642505 (-) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HIY_RS08295 | 1637488..1638456 | - | 969 | WP_011272504.1 | helix-turn-helix transcriptional regulator | - |
| HIY_RS08300 | 1638590..1638796 | + | 207 | WP_006995067.1 | helix-turn-helix domain-containing protein | - |
| HIY_RS08305 | 1638840..1639292 | + | 453 | WP_005651123.1 | hypothetical protein | - |
| HIY_RS08310 | 1639338..1639571 | + | 234 | WP_005651121.1 | helix-turn-helix domain-containing protein | - |
| HIY_RS08315 | 1639573..1640355 | + | 783 | WP_011272503.1 | helix-turn-helix domain-containing protein | - |
| HIY_RS08320 | 1640340..1640975 | + | 636 | WP_011272502.1 | replication P | - |
| HIY_RS08325 | 1640972..1641562 | + | 591 | WP_011272501.1 | N-6-adenine methyltransferase | - |
| HIY_RS08330 | 1641567..1642076 | + | 510 | WP_005692600.1 | DUF1367 family protein | - |
| HIY_RS08335 | 1642077..1642505 | - | 429 | WP_005692602.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| HIY_RS08340 | 1642536..1642721 | - | 186 | WP_005643265.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| HIY_RS08345 | 1642877..1643464 | + | 588 | WP_011272500.1 | recombination protein NinG | - |
| HIY_RS08350 | 1643466..1643831 | + | 366 | WP_005651107.1 | hypothetical protein | - |
| HIY_RS08355 | 1643894..1644754 | + | 861 | WP_011272498.1 | hypothetical protein | - |
| HIY_RS08360 | 1644765..1645913 | + | 1149 | WP_005651101.1 | type I restriction enzyme HsdR N-terminal domain-containing protein | - |
| HIY_RS08365 | 1646074..1646259 | + | 186 | WP_005651099.1 | hypothetical protein | - |
| HIY_RS08370 | 1646645..1646956 | + | 312 | WP_005651098.1 | hypothetical protein | - |
| HIY_RS08375 | 1647075..1647326 | + | 252 | WP_005688811.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | hgpC | 1603549..1661894 | 58345 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6716.88 Da Isoelectric Point: 11.1595
>T36603 WP_005643265.1 NZ_AP022867:c1642721-1642536 [Haemophilus influenzae]
MRSSDLIKELKSAGCTFVRHGKGDHQIWQSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
MRSSDLIKELKSAGCTFVRHGKGDHQIWQSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
Download Length: 186 bp
>T36603 NZ_AP022867:c1642721-1642536 [Haemophilus influenzae]
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCCGTACCGCATCCAAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCCGTACCGCATCCAAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG
Antitoxin
Download Length: 143 a.a. Molecular weight: 16458.45 Da Isoelectric Point: 4.3241
>AT36603 WP_005692602.1 NZ_AP022867:c1642505-1642077 [Haemophilus influenzae]
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINELQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINELQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ
Download Length: 429 bp
>AT36603 NZ_AP022867:c1642505-1642077 [Haemophilus influenzae]
ATGTTATTCACTATCGGCATTGAAACCCCAACAAACGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAGGAAATCCCAACGCAGGTGACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAACGAACTTCAAGATAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATCTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA
ATGTTATTCACTATCGGCATTGAAACCCCAACAAACGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAGGAAATCCCAACGCAGGTGACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAACGAACTTCAAGATAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATCTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|