Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 763271..763908 Replicon chromosome
Accession NZ_AP022867
Organism Haemophilus influenzae strain 2018-Y40

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0H3PFA4
Locus tag HIY_RS03985 Protein ID WP_005656317.1
Coordinates 763271..763675 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag HIY_RS03990 Protein ID WP_005656316.1
Coordinates 763672..763908 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIY_RS03955 758832..759398 + 567 WP_005544066.1 elongation factor P -
HIY_RS03965 759746..760336 - 591 WP_005656319.1 primosomal replication protein -
HIY_RS03970 760369..761721 - 1353 WP_005649062.1 Na+/H+ antiporter family protein -
HIY_RS03975 762035..762724 - 690 WP_005654067.1 ribonuclease T -
HIY_RS03980 762798..763205 - 408 WP_005656318.1 lactoylglutathione lyase -
HIY_RS03985 763271..763675 - 405 WP_005656317.1 type II toxin-antitoxin system VapC family toxin Toxin
HIY_RS03990 763672..763908 - 237 WP_005656316.1 antitoxin Antitoxin
HIY_RS03995 764001..764726 - 726 WP_005656315.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
HIY_RS04000 764779..765297 - 519 WP_005656314.1 isoprenylcysteine carboxyl methyltransferase family protein -
HIY_RS04005 765516..767282 + 1767 WP_005656313.1 aspartate--tRNA ligase -
HIY_RS04010 767304..767780 + 477 WP_005656312.1 dihydroneopterin triphosphate diphosphatase -
HIY_RS04015 767940..768680 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T36601 WP_005656317.1 NZ_AP022867:c763675-763271 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFLTYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T36601 NZ_AP022867:c763675-763271 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTCTTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT36601 WP_005656316.1 NZ_AP022867:c763908-763672 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT36601 NZ_AP022867:c763908-763672 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PFA4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References