36600

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 626956..627434 Replicon chromosome
Accession NZ_AP022867
Organism Haemophilus influenzae strain 2018-Y40

Toxin (Protein)


Gene name VapD Uniprot ID A0A0H3PEZ5
Locus tag HIY_RS03245 Protein ID WP_005656500.1
Coordinates 627156..627434 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag HIY_RS03240 Protein ID WP_005649350.1
Coordinates 626956..627147 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIY_RS03215 622535..623167 + 633 WP_005656505.1 dTMP kinase -
HIY_RS03220 623164..624147 + 984 WP_005659773.1 DNA polymerase III subunit delta' -
HIY_RS03225 624202..624984 + 783 WP_005656503.1 YchF/TatD family DNA exonuclease -
HIY_RS03230 625011..625535 + 525 WP_005656502.1 DUF1523 family protein -
HIY_RS03235 625586..626884 + 1299 WP_032821894.1 hemolysin family protein -
HIY_RS03240 626956..627147 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
HIY_RS03245 627156..627434 + 279 WP_005656500.1 virulence-associated protein VapD Toxin
HIY_RS03250 627527..628057 + 531 WP_005656499.1 hypothetical protein -
HIY_RS03255 628129..629628 + 1500 WP_005656498.1 fused PTS fructose transporter subunit IIA/HPr protein -
HIY_RS03260 629630..630571 + 942 WP_005656497.1 1-phosphofructokinase -
HIY_RS03265 630573..632243 + 1671 WP_005656496.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 5.7408

>T36600 WP_005656500.1 NZ_AP022867:627156-627434 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T36600 NZ_AP022867:627156-627434 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGTGTTCAACAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCTGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT36600 WP_005649350.1 NZ_AP022867:626956-627147 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT36600 NZ_AP022867:626956-627147 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References