Detailed information of TA system TA036599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 368184..368694
• Replicon: chromosome
• Accession: NZ_AP022867
• Organism: Haemophilus influenzae strain 2018-Y40

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A0H3PB74
• Locus tag: HIY_RS01840
• Protein ID: WP_005658624.1
• Coordinates: 368184..368405 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: HIY_RS01845
• Protein ID: WP_005650837.1
• Coordinates: 368398..368694 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIY_RS01835	365026..368077	+	3052	Protein_359	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
HIY_RS01840	368184..368405	+	222	WP_005658624.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HIY_RS01845	368398..368694	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
HIY_RS01850	368861..370777	+	1917	WP_005658626.1	ABC transporter ATP-binding protein	-
HIY_RS01855	370787..371323	+	537	WP_053521035.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
HIY_RS01860	371339..371890	+	552	WP_005658631.1	Sua5/YciO/YrdC/YwlC family protein	-
HIY_RS01865	371894..372700	+	807	WP_005658633.1	shikimate dehydrogenase	-
HIY_RS01870	372712..373464	+	753	WP_005658635.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (10-63)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8834.35 Da
• Isoelectric Point: 10.7588

>T36599 WP_005658624.1 NZ_AP022867:368184-368405 [Haemophilus influenzae]
VQNLLENQALFAILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTTQQRLSELKERLKNE

Nucleotide

• Length: 222 bp

>T36599 NZ_AP022867:368184-368405 [Haemophilus influenzae]
GTGCAAAATCTCCTTGAAAATCAAGCTCTTTTTGCTATTTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCG
CATCTTGTTTGCAAGATTAATGGACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAAC
GAGAAATCCAAACTACCCAACAACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT36599 WP_005650837.1 NZ_AP022867:368398-368694 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT36599 NZ_AP022867:368398-368694 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAACAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTATTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A0H3PB74