Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-DnaT |
Location | 74981..75515 | Replicon | chromosome |
Accession | NZ_AP022867 | ||
Organism | Haemophilus influenzae strain 2018-Y40 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0H3PGA1 |
Locus tag | HIY_RS00370 | Protein ID | WP_005655869.1 |
Coordinates | 75225..75515 (+) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0H3PEU6 |
Locus tag | HIY_RS00365 | Protein ID | WP_005655871.1 |
Coordinates | 74981..75235 (+) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HIY_RS00330 | 70049..70414 | + | 366 | WP_005655888.1 | endonuclease domain-containing protein | - |
HIY_RS00335 | 70554..70970 | + | 417 | WP_005655886.1 | hypothetical protein | - |
HIY_RS00340 | 71016..73082 | + | 2067 | WP_005655883.1 | glycine--tRNA ligase subunit beta | - |
HIY_RS00350 | 73443..74114 | + | 672 | WP_005655881.1 | integrase arm-type DNA-binding domain-containing protein | - |
HIY_RS00355 | 74144..74452 | + | 309 | WP_005655879.1 | P2 family phage major capsid protein | - |
HIY_RS09880 | 74439..74675 | + | 237 | Protein_70 | hypothetical protein | - |
HIY_RS00360 | 74684..74890 | + | 207 | WP_005655873.1 | hypothetical protein | - |
HIY_RS00365 | 74981..75235 | + | 255 | WP_005655871.1 | stability protein StbD | Antitoxin |
HIY_RS00370 | 75225..75515 | + | 291 | WP_005655869.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HIY_RS00375 | 75596..75796 | + | 201 | WP_079997614.1 | hypothetical protein | - |
HIY_RS00380 | 75819..75956 | + | 138 | WP_168769336.1 | hypothetical protein | - |
HIY_RS00385 | 76425..77459 | - | 1035 | WP_005655864.1 | DNA polymerase III subunit delta | - |
HIY_RS00390 | 77459..77962 | - | 504 | WP_005651506.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11510.47 Da Isoelectric Point: 10.6484
>T36598 WP_005655869.1 NZ_AP022867:75225-75515 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLVERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH
MTYKLIFDKRALKEWNKLGETLRQQFKNKLVERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH
Download Length: 291 bp
>T36598 NZ_AP022867:75225-75515 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGTCGAAAGAATGATAAATCCACGTATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACCATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGTCGAAAGAATGATAAATCCACGTATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACCATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9415.78 Da Isoelectric Point: 4.0737
>AT36598 WP_005655871.1 NZ_AP022867:74981-75235 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRIANERLATLEPIEVD
LNDL
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRIANERLATLEPIEVD
LNDL
Download Length: 255 bp
>AT36598 NZ_AP022867:74981-75235 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACGCCTGAATTATTTTCTCATA
TGCAAGAGCTAATCGAAGATTTAGAGCTCGGCAGAATAGCAAATGAACGGCTAGCCACCCTAGAACCTATAGAGGTTGAT
CTAAATGACTTATAA
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACGCCTGAATTATTTTCTCATA
TGCAAGAGCTAATCGAAGATTTAGAGCTCGGCAGAATAGCAAATGAACGGCTAGCCACCCTAGAACCTATAGAGGTTGAT
CTAAATGACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3PGA1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3PEU6 |