Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 74981..75515 Replicon chromosome
Accession NZ_AP022867
Organism Haemophilus influenzae strain 2018-Y40

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3PGA1
Locus tag HIY_RS00370 Protein ID WP_005655869.1
Coordinates 75225..75515 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0H3PEU6
Locus tag HIY_RS00365 Protein ID WP_005655871.1
Coordinates 74981..75235 (+) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIY_RS00330 70049..70414 + 366 WP_005655888.1 endonuclease domain-containing protein -
HIY_RS00335 70554..70970 + 417 WP_005655886.1 hypothetical protein -
HIY_RS00340 71016..73082 + 2067 WP_005655883.1 glycine--tRNA ligase subunit beta -
HIY_RS00350 73443..74114 + 672 WP_005655881.1 integrase arm-type DNA-binding domain-containing protein -
HIY_RS00355 74144..74452 + 309 WP_005655879.1 P2 family phage major capsid protein -
HIY_RS09880 74439..74675 + 237 Protein_70 hypothetical protein -
HIY_RS00360 74684..74890 + 207 WP_005655873.1 hypothetical protein -
HIY_RS00365 74981..75235 + 255 WP_005655871.1 stability protein StbD Antitoxin
HIY_RS00370 75225..75515 + 291 WP_005655869.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HIY_RS00375 75596..75796 + 201 WP_079997614.1 hypothetical protein -
HIY_RS00380 75819..75956 + 138 WP_168769336.1 hypothetical protein -
HIY_RS00385 76425..77459 - 1035 WP_005655864.1 DNA polymerase III subunit delta -
HIY_RS00390 77459..77962 - 504 WP_005651506.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-83)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11510.47 Da        Isoelectric Point: 10.6484

>T36598 WP_005655869.1 NZ_AP022867:75225-75515 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLVERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T36598 NZ_AP022867:75225-75515 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGTCGAAAGAATGATAAATCCACGTATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACCATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9415.78 Da        Isoelectric Point: 4.0737

>AT36598 WP_005655871.1 NZ_AP022867:74981-75235 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRIANERLATLEPIEVD
LNDL

Download         Length: 255 bp

>AT36598 NZ_AP022867:74981-75235 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACGCCTGAATTATTTTCTCATA
TGCAAGAGCTAATCGAAGATTTAGAGCTCGGCAGAATAGCAAATGAACGGCTAGCCACCCTAGAACCTATAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3PGA1


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PEU6

References