Detailed information of TA system TA036595

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 3028246..3028775
• Replicon: chromosome
• Accession: NZ_AP022856
• Organism: Corynebacterium glutamicum strain ATCC 21799

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HT092_RS13970
• Protein ID: WP_075348157.1
• Coordinates: 3028476..3028775 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1B4WJV4
• Locus tag: HT092_RS13965
• Protein ID: WP_060564305.1
• Coordinates: 3028246..3028479 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HT092_RS13945	3024291..3025514	-	1224	WP_004568082.1	esterase family protein	-
HT092_RS13950	3025710..3026795	+	1086	WP_004568081.1	redox-regulated ATPase YchF	-
HT092_RS13955	3026960..3027205	+	246	WP_060564304.1	hypothetical protein	-
HT092_RS13960	3027539..3027979	+	441	WP_038583357.1	YtoQ family protein	-
HT092_RS13965	3028246..3028479	+	234	WP_060564305.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HT092_RS13970	3028476..3028775	+	300	WP_075348157.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HT092_RS13975	3028814..3029080	+	267	WP_087061857.1	helix-turn-helix transcriptional regulator	-
HT092_RS13980	3029298..3029771	-	474	WP_081302985.1	SAP domain-containing protein	-
HT092_RS13985	3029937..3030449	-	513	WP_146144404.1	hypothetical protein	-
HT092_RS13990	3030669..3031127	+	459	WP_060564309.1	NUDIX domain-containing protein	-
HT092_RS13995	3031291..3031674	+	384	WP_060564310.1	class I SAM-dependent methyltransferase	-
HT092_RS14000	3031824..3032849	-	1026	WP_065366767.1	hypothetical protein	-
HT092_RS14005	3032854..3033432	-	579	WP_060564312.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-74)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11529.07 Da
• Isoelectric Point: 10.6281

>T36595 WP_075348157.1 NZ_AP022856:3028476-3028775 [Corynebacterium glutamicum]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGRSREEIRLGYKSTAVGSHVIFYVQRTSHW
KAMKQPVWRPTSARQFVTS

Nucleotide

• Length: 300 bp

>T36595 NZ_AP022856:3028476-3028775 [Corynebacterium glutamicum]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCCGTAGTC
GTGAGGAAATTCGCTTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGCCATTGG
AAGGCAATGAAACAGCCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8475.39 Da
• Isoelectric Point: 4.1948

>AT36595 WP_060564305.1 NZ_AP022856:3028246-3028479 [Corynebacterium glutamicum]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGEMSGEAEEFDFDAFIASKSS

Nucleotide

• Length: 234 bp

>AT36595 NZ_AP022856:3028246-3028479 [Corynebacterium glutamicum]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAGAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4WJV4