Detailed information of TA system TA036594

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 3249659..3251130
• Replicon: chromosome
• Accession: NZ_AP022853
• Organism: Sulfurimicrobium lacus strain skT11

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: SKTS_RS15820
• Protein ID: WP_173067202.1
• Coordinates: 3250258..3251130 (+)
• Length: 291 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: SKTS_RS15815
• Protein ID: WP_173067199.1
• Coordinates: 3249659..3250261 (+)
• Length: 201 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SKTS_RS15790	3245375..3245710	-	336	WP_173067187.1	helix-turn-helix domain-containing protein	-
SKTS_RS15795	3245956..3247191	+	1236	WP_173067190.1	hypothetical protein	-
SKTS_RS15800	3247195..3248148	+	954	WP_173067193.1	hypothetical protein	-
SKTS_RS15805	3248275..3248505	+	231	WP_173067196.1	DUF2188 domain-containing protein	-
SKTS_RS18840	3249079..3249552	+	474	WP_198420380.1	helix-turn-helix domain-containing protein	-
SKTS_RS15815	3249659..3250261	+	603	WP_173067199.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
SKTS_RS15820	3250258..3251130	+	873	WP_173067202.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
SKTS_RS15825	3251495..3252808	-	1314	WP_173067205.1	IS1380 family transposase	-
SKTS_RS15830	3252990..3254045	+	1056	WP_173067208.1	ISNCY family transposase	-
SKTS_RS15835	3254071..3254682	+	612	WP_173067211.1	hypothetical protein	-
SKTS_RS15840	3254726..3255487	-	762	WP_173067214.1	DISARM system phospholipase D-like protein DrmC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3204027..3254045	50018

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (35-266)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (8-55)

Sequences

Toxin

Protein

• Length: 291 a.a.
• Molecular weight: 31607.53 Da
• Isoelectric Point: 6.5002

>T36594 WP_173067202.1 NZ_AP022853:3250258-3251130 [Sulfurimicrobium lacus]
MNKDIAASVRARLLNLAKAQGVDFNQVLVRFALERILYRLSQSEHADRFLLKGALLFTLWYDMPHRPTRDADLLGFGPSD
LDSIAQTFRDIASVNVADGMVFDPASVTAEEIRKEAGYAGARVLISGEIAKARCKTQIDIGFGDAVTPGPVDATYPVLIN
DLPAPRLRTYPVYTVIAEKLHAIALLGMTNSRLKDYLDLLVLLDRETLDAETLAGAIAATFIRRGMAVPASLPVGLTDEF
SGDATRQALWHAFLKKNELAQQALPDVVAVLRTALEPALIRAATLNGLQK

Nucleotide

• Length: 873 bp

>T36594 NZ_AP022853:3250258-3251130 [Sulfurimicrobium lacus]
ATGAACAAGGACATCGCCGCCTCCGTCCGGGCACGTCTGCTCAATCTCGCCAAGGCGCAGGGAGTGGATTTCAATCAGGT
GCTGGTTCGCTTCGCCCTGGAGCGCATCCTCTACCGCCTGAGCCAATCGGAGCACGCCGACCGTTTTCTACTCAAGGGCG
CGCTGTTGTTCACCCTCTGGTACGACATGCCCCATCGCCCGACGCGCGATGCCGACCTGCTCGGCTTCGGGCCCAGCGAT
TTGGACTCCATTGCCCAGACGTTTCGGGACATCGCCAGCGTCAATGTCGCCGATGGCATGGTTTTCGATCCGGCATCGGT
CACCGCCGAGGAAATCCGCAAGGAGGCCGGCTATGCCGGTGCTCGGGTACTGATCAGCGGCGAAATCGCCAAGGCACGCT
GCAAGACGCAGATCGATATCGGTTTCGGCGATGCGGTCACGCCCGGGCCGGTCGACGCAACCTACCCAGTACTGATCAAT
GATCTGCCAGCACCACGACTTCGTACCTATCCCGTTTACACCGTCATCGCAGAAAAGTTGCATGCCATCGCTTTGCTGGG
CATGACCAACAGCCGGTTGAAGGACTATCTCGATTTGTTGGTGCTGCTGGATCGTGAAACGCTGGATGCTGAAACCTTGG
CCGGCGCGATCGCGGCCACCTTCATCCGGCGCGGCATGGCAGTTCCGGCTTCGCTGCCGGTCGGCCTGACGGATGAGTTT
TCAGGTGACGCGACACGGCAAGCCCTGTGGCACGCGTTTCTCAAGAAGAACGAACTGGCCCAACAAGCGCTACCGGATGT
CGTGGCCGTGCTGCGAACGGCACTGGAGCCGGCACTAATTCGTGCTGCAACGCTGAACGGGCTCCAGAAATAG

Antitoxin

Protein

• Length: 201 a.a.
• Molecular weight: 22405.27 Da
• Isoelectric Point: 9.7821

>AT36594 WP_173067199.1 NZ_AP022853:3249659-3250261 [Sulfurimicrobium lacus]
MREATQTQRVIDLLAQKGMLRPIDLDAMGIPRVVLTRMSTAGQLEKIGRGLYRLPSPGSENESLVAIATKVPQAVFCLLT
ALQFHELTTQLPRQIWIAMPRGSHTPKIDYPPVKMVQFAGEAYSAGIEEVERDQVKLRVYCAAKTVADCFKHRNKIGLDV
ALEALKDARAKKKASADELWRYAKICRVANVMRPYLEAIE

Nucleotide

• Length: 603 bp

>AT36594 NZ_AP022853:3249659-3250261 [Sulfurimicrobium lacus]
ATGCGTGAAGCCACTCAAACCCAGCGCGTTATCGATCTGCTTGCCCAGAAGGGGATGCTGCGCCCAATCGATCTGGACGC
CATGGGCATCCCTCGGGTGGTGCTGACGCGCATGAGCACCGCTGGCCAGCTCGAGAAAATCGGCCGTGGCCTCTATCGCC
TGCCAAGCCCTGGCTCCGAAAACGAGAGCCTGGTCGCCATCGCGACCAAGGTGCCACAGGCGGTTTTTTGCCTGCTCACG
GCCCTGCAATTCCATGAACTGACCACCCAACTGCCGCGCCAGATCTGGATCGCCATGCCTCGGGGCAGCCACACCCCGAA
AATCGATTATCCGCCGGTCAAGATGGTGCAGTTCGCCGGGGAGGCTTATTCGGCAGGGATCGAGGAGGTCGAGCGCGACC
AAGTCAAGCTGCGGGTCTACTGCGCAGCCAAGACCGTGGCCGACTGCTTCAAGCACCGCAACAAGATCGGCCTGGACGTG
GCGCTCGAAGCCCTAAAAGATGCCCGGGCAAAAAAGAAGGCTTCGGCCGACGAGCTCTGGCGCTACGCCAAGATCTGTCG
CGTCGCCAACGTGATGCGCCCCTACCTCGAGGCCATCGAATGA