Detailed information of TA system TA036593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 3025994..3026595
• Replicon: chromosome
• Accession: NZ_AP022853
• Organism: Sulfurimicrobium lacus strain skT11

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: SKTS_RS14620
• Protein ID: WP_173066568.1
• Coordinates: 3025994..3026290 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: SKTS_RS14625
• Protein ID: WP_173066571.1
• Coordinates: 3026296..3026595 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SKTS_RS14595	3021585..3024158	+	2574	WP_173066555.1	YgiQ family radical SAM protein	-
SKTS_RS14600	3024214..3024492	+	279	WP_173066558.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SKTS_RS14605	3024504..3024803	+	300	WP_173066562.1	HigA family addiction module antidote protein	-
SKTS_RS14610	3024813..3025413	-	601	Protein_2869	uracil-DNA glycosylase family protein	-
SKTS_RS14615	3025595..3025843	+	249	WP_173066565.1	hypothetical protein	-
SKTS_RS14620	3025994..3026290	+	297	WP_173066568.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SKTS_RS14625	3026296..3026595	+	300	WP_173066571.1	putative addiction module antidote protein	Antitoxin
SKTS_RS14630	3026653..3027060	+	408	WP_173066574.1	hypothetical protein	-
SKTS_RS14635	3027190..3027504	+	315	WP_173066577.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SKTS_RS14640	3027508..3027792	+	285	WP_173066580.1	helix-turn-helix domain-containing protein	-
SKTS_RS14645	3027817..3028236	+	420	WP_173066582.1	thioesterase family protein	-
SKTS_RS14650	3028330..3028500	-	171	WP_173066585.1	hypothetical protein	-
SKTS_RS14655	3028754..3029455	+	702	WP_173066588.1	hypothetical protein	-
SKTS_RS14660	3029477..3031435	-	1959	WP_173066590.1	DUF839 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-92)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10927.59 Da
• Isoelectric Point: 9.9959

>T36593 WP_173066568.1 NZ_AP022853:3025994-3026290 [Sulfurimicrobium lacus]
MIEIRKTGLFAQWLDALCDLQARARVQTRIERLAAGNPGDVEPVGEGVSELRINYGPGYRVYFKQRGRELIILLAGGDKS
TQAKDIKTALRLARNLSE

Nucleotide

• Length: 297 bp

>T36593 NZ_AP022853:3025994-3026290 [Sulfurimicrobium lacus]
ATGATTGAAATCCGCAAAACTGGCCTTTTCGCTCAATGGCTGGACGCGTTGTGCGATCTTCAGGCGAGAGCGCGCGTCCA
AACAAGAATCGAACGGCTCGCGGCGGGAAACCCTGGAGATGTCGAGCCGGTTGGCGAAGGTGTCTCGGAATTGCGAATCA
ACTACGGTCCCGGCTACCGGGTATATTTCAAGCAGCGAGGGCGAGAGCTGATTATTCTGCTGGCTGGCGGGGACAAGAGT
ACCCAAGCCAAAGACATCAAGACCGCCTTGCGCCTCGCACGTAATCTTTCGGAGTAG

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10562.01 Da
• Isoelectric Point: 6.2230

>AT36593 WP_173066571.1 NZ_AP022853:3026296-3026595 [Sulfurimicrobium lacus]
MTKTVTTRYDVAEHLRTPEEMAAYLEACLEEANGDAAFIAKALGDIARAKGMSQVARDAGLSRESLYKALSGERSPGFDT
ILKVIGALGLKLHAEAGHN

Nucleotide

• Length: 300 bp

>AT36593 NZ_AP022853:3026296-3026595 [Sulfurimicrobium lacus]
ATGACCAAGACTGTTACCACCCGCTATGACGTCGCTGAACACCTCAGAACCCCAGAGGAAATGGCTGCTTATCTTGAAGC
CTGCCTTGAAGAAGCCAACGGGGATGCTGCATTCATCGCCAAGGCACTTGGCGACATTGCTCGCGCCAAGGGTATGTCGC
AGGTCGCGCGCGATGCCGGACTGTCCCGCGAAAGCCTTTACAAGGCGCTTTCCGGTGAGCGTAGCCCGGGCTTCGATACC
ATCCTTAAAGTCATCGGCGCGCTTGGGCTGAAGTTGCATGCCGAAGCCGGTCACAACTGA