Detailed information of TA system TA036592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-YefM
• Location: 2207453..2207955
• Replicon: chromosome
• Accession: NZ_AP022853
• Organism: Sulfurimicrobium lacus strain skT11

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: SKTS_RS10885
• Protein ID: WP_173064549.1
• Coordinates: 2207453..2207716 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SKTS_RS10890
• Protein ID: WP_173064552.1
• Coordinates: 2207713..2207955 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SKTS_RS10875	2202971..2205571	+	2601	WP_173064543.1	EAL domain-containing protein	-
SKTS_RS10880	2205615..2207396	-	1782	WP_173064546.1	N-acetylglutaminylglutamine amidotransferase	-
SKTS_RS10885	2207453..2207716	-	264	WP_173064549.1	Txe/YoeB family addiction module toxin	Toxin
SKTS_RS10890	2207713..2207955	-	243	WP_173064552.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SKTS_RS10895	2208106..2208927	-	822	WP_173064555.1	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	-
SKTS_RS10900	2208943..2210139	-	1197	WP_173064558.1	succinyldiaminopimelate transaminase	-
SKTS_RS10905	2210237..2211124	+	888	WP_173064560.1	DMT family transporter	-
SKTS_RS10910	2211111..2211488	+	378	WP_173064563.1	VOC family protein	-
SKTS_RS10915	2211496..2212401	+	906	WP_173064566.1	AEC family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10022.58 Da
• Isoelectric Point: 9.8078

>T36592 WP_173064549.1 NZ_AP022853:c2207716-2207453 [Sulfurimicrobium lacus]
VTWQLVYTKQAQNDAKKLAAAGLKQKAQELLAILVANPFQNPPPFEKLVGDLNGAYSRRINIQHRLVYQVLDEEHVVKVL
RLWSHYE

Nucleotide

• Length: 264 bp

>T36592 NZ_AP022853:c2207716-2207453 [Sulfurimicrobium lacus]
GTGACGTGGCAACTTGTCTATACCAAGCAAGCGCAAAACGATGCAAAGAAGCTTGCAGCCGCTGGCCTCAAGCAGAAAGC
GCAGGAGTTGTTGGCCATTCTGGTTGCCAACCCCTTTCAGAACCCTCCGCCATTCGAGAAACTGGTTGGAGACCTTAACG
GTGCATACTCGCGGCGTATCAACATTCAGCACCGTCTGGTTTACCAGGTTCTCGACGAAGAGCATGTCGTCAAGGTGCTC
CGCTTGTGGAGCCACTACGAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8927.15 Da
• Isoelectric Point: 4.4000

>AT36592 WP_173064552.1 NZ_AP022853:c2207955-2207713 [Sulfurimicrobium lacus]
MTTITASEARSKLYRLMDDAASSHEPILITGKRANAVLLSEQDWASIQESLFLLSVPGMRESIVEGLKTSLDECTRELDW

Nucleotide

• Length: 243 bp

>AT36592 NZ_AP022853:c2207955-2207713 [Sulfurimicrobium lacus]
ATGACGACCATCACGGCAAGCGAAGCGCGCTCAAAGCTCTATCGCCTCATGGATGATGCGGCTTCGTCTCATGAGCCCAT
CCTGATTACCGGTAAGCGGGCAAATGCCGTTCTGCTTTCGGAACAGGATTGGGCTTCGATCCAGGAATCGCTATTTCTGC
TGTCGGTTCCCGGCATGAGGGAATCCATTGTCGAGGGGCTTAAAACCTCGCTTGACGAGTGCACCCGGGAGCTTGATTGG
TGA