Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1539338..1540008 Replicon chromosome
Accession NZ_AP022853
Organism Sulfurimicrobium lacus strain skT11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SKTS_RS07660 Protein ID WP_173062691.1
Coordinates 1539338..1539760 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SKTS_RS07665 Protein ID WP_173062694.1
Coordinates 1539757..1540008 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SKTS_RS07625 1535010..1535399 - 390 WP_198420484.1 3-hydroxylacyl-ACP dehydratase -
SKTS_RS07630 1535453..1536295 - 843 WP_173062674.1 beta-ketoacyl synthase chain length factor -
SKTS_RS07635 1536292..1537515 - 1224 WP_173062677.1 beta-ketoacyl-[acyl-carrier-protein] synthase family protein -
SKTS_RS07640 1537556..1537900 - 345 WP_173062680.1 DUF86 domain-containing protein -
SKTS_RS07645 1537893..1538183 - 291 WP_173062683.1 nucleotidyltransferase family protein -
SKTS_RS07650 1538406..1538687 - 282 WP_173062686.1 DUF2442 domain-containing protein -
SKTS_RS07655 1538684..1538953 - 270 WP_198420448.1 DUF4160 domain-containing protein -
SKTS_RS07660 1539338..1539760 - 423 WP_173062691.1 type II toxin-antitoxin system VapC family toxin Toxin
SKTS_RS07665 1539757..1540008 - 252 WP_173062694.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SKTS_RS07670 1540179..1541546 + 1368 WP_173069071.1 LOG family protein -
SKTS_RS07675 1541578..1541856 + 279 WP_173062697.1 hypothetical protein -
SKTS_RS07680 1543022..1544827 - 1806 WP_173062712.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-67)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15578.04 Da        Isoelectric Point: 6.7098

>T36591 WP_173062691.1 NZ_AP022853:c1539760-1539338 [Sulfurimicrobium lacus]
MSWLLDTCTLSEYARKAPARKVISWLDEQDEASLFISVITLGEIEKGILKLRASDPSRSQKLTAWLGKVEQRFAGRILPL
DTAALHVWAQIAAHSELAGQPLPVMDGLLMATAQCHGFTVVTRNVQDFALYPQVYNPWAL

Download         Length: 423 bp

>T36591 NZ_AP022853:c1539760-1539338 [Sulfurimicrobium lacus]
ATGAGCTGGCTGCTGGATACCTGCACGCTTTCCGAATACGCCAGGAAAGCTCCCGCGCGGAAAGTGATTTCCTGGCTCGA
CGAGCAGGACGAAGCCAGCCTGTTCATCAGCGTGATTACCCTGGGGGAGATCGAAAAAGGCATCCTCAAGCTGCGCGCCA
GCGACCCGAGCCGCAGCCAGAAACTTACAGCCTGGCTGGGCAAGGTGGAGCAGCGCTTCGCCGGGCGCATCCTGCCGCTC
GACACCGCCGCGCTTCATGTCTGGGCGCAAATCGCCGCACACTCGGAATTGGCCGGACAACCCCTGCCGGTGATGGACGG
CCTGCTCATGGCCACCGCCCAATGCCACGGATTCACCGTAGTCACCCGCAACGTGCAGGATTTTGCGTTGTACCCGCAAG
TCTATAATCCTTGGGCGCTGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9204.41 Da        Isoelectric Point: 7.2038

>AT36591 WP_173062694.1 NZ_AP022853:c1540008-1539757 [Sulfurimicrobium lacus]
MHSEWQLQEAKGNFSQLIKRAASGDAQMVTVHGKPTAVVVSAEEYARLTRRRGKLSSALLQPDLAIEDLDLARSRDTGRD
IEL

Download         Length: 252 bp

>AT36591 NZ_AP022853:c1540008-1539757 [Sulfurimicrobium lacus]
ATGCATAGCGAATGGCAACTACAAGAAGCGAAGGGCAACTTCAGCCAGCTCATCAAGCGGGCGGCGAGTGGCGATGCCCA
AATGGTCACCGTCCACGGCAAACCCACGGCGGTAGTCGTTTCGGCGGAAGAATACGCCCGGCTCACGCGTCGCCGGGGCA
AGCTTTCCAGCGCGCTGCTGCAACCCGATCTCGCCATCGAAGACCTCGATCTCGCGCGCAGCCGCGACACCGGGCGCGAC
ATCGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References