Detailed information of TA system TA036584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2036031..2036534
• Replicon: chromosome
• Accession: NZ_AP022848
• Organism: Bosea sp. ANAM02

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: OCUBac02_RS09775
• Protein ID: WP_173045263.1
• Coordinates: 2036340..2036534 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: OCUBac02_RS09770
• Protein ID: WP_173045261.1
• Coordinates: 2036031..2036327 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCUBac02_RS09745	2032617..2032853	+	237	WP_047576443.1	hypothetical protein	-
OCUBac02_RS09750	2033085..2034032	-	948	WP_173045255.1	50S ribosomal protein L11 methyltransferase	-
OCUBac02_RS09755	2034309..2035064	-	756	WP_173045257.1	SDR family oxidoreductase	-
OCUBac02_RS09760	2035188..2035586	+	399	WP_197064300.1	helix-turn-helix transcriptional regulator	-
OCUBac02_RS09765	2035591..2036013	-	423	WP_173045259.1	GNAT family N-acetyltransferase	-
OCUBac02_RS09770	2036031..2036327	-	297	WP_173045261.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
OCUBac02_RS09775	2036340..2036534	-	195	WP_173045263.1	type II toxin-antitoxin system HicA family toxin	Toxin
OCUBac02_RS09780	2036659..2039169	-	2511	WP_173045265.1	UvrD-helicase domain-containing protein	-
OCUBac02_RS09785	2039269..2040966	+	1698	WP_173045267.1	acyl-CoA dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-78)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7380.53 Da
• Isoelectric Point: 11.2348

>T36584 WP_173045263.1 NZ_AP022848:c2036534-2036340 [Bosea sp. ANAM02]
MLTNSADIIRRLKRDGFALKSTRGSHQKFVHEATKRMVIVPHPKRDIPIGTVHAIYRDAGWDRD

Nucleotide

• Length: 195 bp

>T36584 NZ_AP022848:c2036534-2036340 [Bosea sp. ANAM02]
ATGCTTACCAACAGCGCTGACATCATCCGCCGCCTGAAGCGCGATGGCTTCGCCCTGAAGAGCACGCGCGGCTCGCATCA
GAAGTTCGTGCACGAGGCGACGAAACGCATGGTGATCGTGCCCCATCCGAAGCGGGACATTCCAATCGGGACCGTCCATG
CGATATATAGGGATGCCGGCTGGGATCGAGATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10966.11 Da
• Isoelectric Point: 3.9851

>AT36584 WP_173045261.1 NZ_AP022848:c2036327-2036031 [Bosea sp. ANAM02]
MRHYIAVVHKDETSCYGVFFPDVNGVFTAGDTLEEAFAQAQEVLAFAAEHWVEDTASDFPEPRSIDELRTDPDFVESSRD
AILMAIPFNQTPTRIAAE

Nucleotide

• Length: 297 bp

>AT36584 NZ_AP022848:c2036327-2036031 [Bosea sp. ANAM02]
ATGCGACACTACATTGCAGTCGTCCACAAGGACGAGACATCCTGCTACGGCGTGTTTTTTCCGGATGTGAACGGCGTGTT
CACGGCTGGCGATACGCTGGAAGAGGCGTTCGCCCAGGCACAGGAAGTCCTCGCATTTGCGGCAGAACACTGGGTCGAGG
ATACAGCTTCCGATTTTCCCGAGCCGCGCTCGATCGACGAGTTGCGAACCGATCCGGACTTTGTCGAATCGTCCAGGGAC
GCCATCCTGATGGCCATTCCGTTTAATCAGACACCGACCCGTATCGCCGCCGAGTAA