Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1321335..1321969 Replicon chromosome
Accession NZ_AP022847
Organism Nitrosophilus alvini strain EPR55-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EPR_RS06760 Protein ID WP_200762484.1
Coordinates 1321568..1321969 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EPR_RS06755 Protein ID WP_200762483.1
Coordinates 1321335..1321571 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPR_RS06740 1316811..1317188 - 378 WP_200762480.1 hypothetical protein -
EPR_RS06745 1317692..1320313 + 2622 WP_200762481.1 DEAD/DEAH box helicase -
EPR_RS06750 1320327..1321028 + 702 WP_200762482.1 hypothetical protein -
EPR_RS06755 1321335..1321571 + 237 WP_200762483.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EPR_RS06760 1321568..1321969 + 402 WP_200762484.1 type II toxin-antitoxin system VapC family toxin Toxin
EPR_RS06765 1322159..1323268 + 1110 WP_200762485.1 ATP-binding protein -
EPR_RS06770 1323402..1324133 - 732 WP_200762486.1 hypothetical protein -
EPR_RS06775 1324485..1325408 + 924 WP_200762487.1 WYL domain-containing protein -
EPR_RS06780 1325483..1326493 + 1011 WP_200762488.1 hypothetical protein -
EPR_RS06785 1326556..1326924 + 369 WP_200762489.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-56)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15187.76 Da        Isoelectric Point: 8.8969

>T36582 WP_200762484.1 NZ_AP022847:1321568-1321969 [Nitrosophilus alvini]
MKKRMLDTNICIYIIKNRPTTVLKKFKDFNIGDLAISCITVSELYYGAYKSKYTEKNLKALEDFLYPFDIIEFDENAAVE
YGKIRASLEKKGLIIGGLDMLIAASAKSQGMVLVTNNTKEFSRIDNLKIENWV

Download         Length: 402 bp

>T36582 NZ_AP022847:1321568-1321969 [Nitrosophilus alvini]
TTGAAAAAGAGAATGTTAGATACCAATATCTGTATCTATATTATAAAAAACAGACCGACAACTGTTTTGAAAAAATTCAA
AGATTTTAATATAGGAGATTTGGCAATTTCATGTATAACTGTGTCTGAACTCTATTATGGAGCTTATAAAAGTAAATATA
CGGAAAAAAATCTAAAAGCTCTTGAGGATTTCCTTTATCCTTTTGATATTATCGAATTTGACGAAAACGCCGCCGTTGAA
TATGGGAAAATAAGAGCCTCATTAGAAAAAAAAGGACTAATCATAGGTGGGCTTGATATGTTGATTGCAGCAAGTGCAAA
ATCCCAAGGAATGGTGCTTGTGACAAACAACACTAAAGAGTTTAGCAGGATTGACAATCTAAAAATTGAAAACTGGGTAT
AA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9381.87 Da        Isoelectric Point: 10.0109

>AT36582 WP_200762483.1 NZ_AP022847:1321335-1321571 [Nitrosophilus alvini]
MTATAKLFKNGQSQAVRLPKEFRFENQNEVFVKKYKKGILLIPKTKDIWDVMIRSLDEFSEDFLKERTQPEQKREELF

Download         Length: 237 bp

>AT36582 NZ_AP022847:1321335-1321571 [Nitrosophilus alvini]
ATGACAGCAACAGCAAAACTTTTTAAAAACGGACAAAGCCAAGCGGTCAGACTTCCAAAAGAGTTCAGGTTTGAAAATCA
AAATGAAGTGTTTGTAAAAAAATATAAAAAAGGCATATTGCTCATTCCAAAAACAAAAGATATTTGGGATGTTATGATTA
GAAGCCTTGATGAATTTAGCGAGGATTTTCTAAAAGAAAGAACACAACCTGAGCAAAAAAGAGAGGAACTATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References