Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/YafQ-RelB |
Location | 1256965..1257500 | Replicon | chromosome |
Accession | NZ_AP022846 | ||
Organism | Haemophilus influenzae strain TAMBA230 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | IGS56_RS06165 | Protein ID | WP_071163272.1 |
Coordinates | 1257237..1257500 (+) | Length | 88 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | IGS56_RS06160 | Protein ID | WP_071163271.1 |
Coordinates | 1256965..1257240 (+) | Length | 92 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IGS56_RS06140 | 1252369..1254408 | - | 2040 | WP_071163269.1 | excinuclease ABC subunit B | - |
IGS56_RS06150 | 1255023..1255991 | - | 969 | WP_071163270.1 | zinc transporter permease subunit ZevB | - |
IGS56_RS06155 | 1255994..1256614 | - | 621 | WP_005650213.1 | zinc transporter binding subunit ZevA | - |
IGS56_RS06160 | 1256965..1257240 | + | 276 | WP_071163271.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
IGS56_RS06165 | 1257237..1257500 | + | 264 | WP_071163272.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
IGS56_RS06170 | 1257584..1259254 | + | 1671 | WP_005650218.1 | energy-dependent translational throttle protein EttA | - |
IGS56_RS06175 | 1259317..1259658 | + | 342 | WP_040033872.1 | SirB2 family protein | - |
IGS56_RS06180 | 1259663..1261633 | + | 1971 | WP_103708111.1 | tRNA(Met) cytidine acetyltransferase TmcA | - |
IGS56_RS06185 | 1261630..1261803 | + | 174 | WP_005657572.1 | DUF5363 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10201.90 Da Isoelectric Point: 7.8978
>T36580 WP_071163272.1 NZ_AP022846:1257237-1257500 [Haemophilus influenzae]
MISVSGEYKREFKKHIPLLINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKVVGDEIRLARLN
THSEIFG
MISVSGEYKREFKKHIPLLINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKVVGDEIRLARLN
THSEIFG
Download Length: 264 bp
>T36580 NZ_AP022846:1257237-1257500 [Haemophilus influenzae]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTCTTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCATGCTTTAACTGGAAATTGGAAAGGTT
GGAGAGATTGCCATATAAAGAATGATCTTGTGCTTATTTATAAAGTGGTGGGAGATGAAATAAGGCTGGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTCTTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCATGCTTTAACTGGAAATTGGAAAGGTT
GGAGAGATTGCCATATAAAGAATGATCTTGTGCTTATTTATAAAGTGGTGGGAGATGAAATAAGGCTGGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10277.84 Da Isoelectric Point: 6.0646
>AT36580 WP_071163271.1 NZ_AP022846:1256965-1257240 [Haemophilus influenzae]
MAAVSFRVPDETKNMAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS
MAAVSFRVPDETKNMAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS
Download Length: 276 bp
>AT36580 NZ_AP022846:1256965-1257240 [Haemophilus influenzae]
ATGGCTGCAGTTAGTTTTCGAGTACCTGATGAAACTAAAAATATGGCGTTTGAAGTGATTAAAAGTTACGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCACTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTAGATAATCATCATGGGCATGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTAGCGGAGATGAAATCATGA
ATGGCTGCAGTTAGTTTTCGAGTACCTGATGAAACTAAAAATATGGCGTTTGAAGTGATTAAAAGTTACGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCACTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTAGATAATCATCATGGGCATGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTAGCGGAGATGAAATCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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