36579

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 579775..580112 Replicon chromosome
Accession NZ_AP022846
Organism Haemophilus influenzae strain TAMBA230

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag IGS56_RS02880 Protein ID WP_071162882.1
Coordinates 579975..580112 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag IGS56_RS02875 Protein ID WP_005649350.1
Coordinates 579775..579966 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS56_RS02850 575642..575785 - 144 WP_162626749.1 hypothetical protein -
IGS56_RS02855 575984..576967 + 984 WP_071162884.1 DNA polymerase III subunit delta' -
IGS56_RS02860 577022..577804 + 783 WP_071162883.1 YchF/TatD family DNA exonuclease -
IGS56_RS02865 577831..578355 + 525 WP_005652096.1 DUF1523 family protein -
IGS56_RS02870 578406..579704 + 1299 Protein_543 HlyC/CorC family transporter -
IGS56_RS02875 579775..579966 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
IGS56_RS02880 579975..580112 + 138 WP_071162882.1 virulence-associated protein D Toxin
IGS56_RS02885 580205..580735 + 531 WP_005686915.1 hypothetical protein -
IGS56_RS02890 580807..582306 + 1500 WP_071162881.1 fused PTS fructose transporter subunit IIA/HPr protein -
IGS56_RS02895 582308..583249 + 942 WP_071162880.1 1-phosphofructokinase -
IGS56_RS02900 583251..584921 + 1671 WP_071162879.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5270.90 Da        Isoelectric Point: 4.2907

>T36579 WP_071162882.1 NZ_AP022846:579975-580112 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAFLIEQWSNFTDFIRN

Download         Length: 138 bp

>T36579 NZ_AP022846:579975-580112 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGTGTTCAACAGGCTTATACAGA
CATTGGCGCTTTTCTTATTGAGCAATGGTCTAATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT36579 WP_005649350.1 NZ_AP022846:579775-579966 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT36579 NZ_AP022846:579775-579966 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References