Detailed information of TA system TA036578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 387131..387641
• Replicon: chromosome
• Accession: NZ_AP022846
• Organism: Haemophilus influenzae strain TAMBA230

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A2S9R6L1
• Locus tag: IGS56_RS01895
• Protein ID: WP_038439526.1
• Coordinates: 387131..387352 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: IGS56_RS01900
• Protein ID: WP_005650837.1
• Coordinates: 387345..387641 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IGS56_RS01885	383452..383673	-	222	WP_111688800.1	ABC transporter	-
IGS56_RS01890	384049..387024	+	2976	WP_190811810.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
IGS56_RS01895	387131..387352	+	222	WP_038439526.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IGS56_RS01900	387345..387641	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
IGS56_RS01905	387825..389741	+	1917	WP_042603697.1	ABC transporter ATP-binding protein	-
IGS56_RS01910	389751..390287	+	537	WP_042603698.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
IGS56_RS01915	390303..390854	+	552	WP_042603699.1	Sua5/YciO/YrdC/YwlC family protein	-
IGS56_RS01920	390858..391664	+	807	WP_190811811.1	shikimate dehydrogenase	-
IGS56_RS01925	391878..392441	+	564	WP_103708096.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (10-63)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8804.33 Da
• Isoelectric Point: 10.7588

>T36578 WP_038439526.1 NZ_AP022846:387131-387352 [Haemophilus influenzae]
VQNLLENQALFAILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 222 bp

>T36578 NZ_AP022846:387131-387352 [Haemophilus influenzae]
GTGCAAAATCTCCTTGAAAATCAAGCTCTTTTTGCTATTTTAGACGGTGAAATTTGGGAACTTCGCCCAATTAGGGATCG
CATCTTGTTTGCAAGATTAATGGACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAAC
GAGAAATCCAAACTGCCCAACAACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT36578 WP_005650837.1 NZ_AP022846:387345-387641 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT36578 NZ_AP022846:387345-387641 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGAATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGCTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A2S9R6L1