Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 328763..329367 Replicon chromosome
Accession NZ_AP022846
Organism Haemophilus influenzae strain TAMBA230

Toxin (Protein)


Gene name relE Uniprot ID A0A837MVY4
Locus tag IGS56_RS01615 Protein ID WP_050846512.1
Coordinates 328763..329071 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Y7JSS2
Locus tag IGS56_RS01620 Protein ID WP_005661259.1
Coordinates 329071..329367 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS56_RS01605 323840..325138 - 1299 WP_075985659.1 trigger factor -
IGS56_RS01610 325468..328704 + 3237 WP_190811805.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
IGS56_RS01615 328763..329071 - 309 WP_050846512.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
IGS56_RS01620 329071..329367 - 297 WP_005661259.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IGS56_RS01625 329487..329612 - 126 WP_005654327.1 hypothetical protein -
IGS56_RS01630 329596..331455 - 1860 WP_103708039.1 selenocysteine-specific translation elongation factor -
IGS56_RS01635 331452..332837 - 1386 WP_071162996.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11920.68 Da        Isoelectric Point: 7.8657

>T36576 WP_050846512.1 NZ_AP022846:c329071-328763 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T36576 NZ_AP022846:c329071-328763 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11015.37 Da        Isoelectric Point: 4.4297

>AT36576 WP_005661259.1 NZ_AP022846:c329367-329071 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT36576 NZ_AP022846:c329367-329071 [Haemophilus influenzae]
ATGGCACTTACTAATTCCTCTATCAGTTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837MVY4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Y7JSS2

References