Detailed information of TA system TA036575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3864618..3865528
• Replicon: chromosome
• Accession: NZ_AP022843
• Organism: Halomonas hydrothermalis strain Slthf2

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HHSLTHF2_RS17650
• Protein ID: WP_172422314.1
• Coordinates: 3865064..3865528 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HHSLTHF2_RS17645
• Protein ID: WP_172422313.1
• Coordinates: 3864618..3865067 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHSLTHF2_RS17625	3860721..3861689	+	969	WP_172422309.1	zinc ABC transporter substrate-binding protein	-
HHSLTHF2_RS17630	3861713..3862495	+	783	WP_172422310.1	ABC transporter ATP-binding protein	-
HHSLTHF2_RS17635	3862499..3863593	+	1095	WP_172422311.1	metal ABC transporter permease	-
HHSLTHF2_RS17640	3863590..3864510	+	921	WP_172422312.1	metal ABC transporter permease	-
HHSLTHF2_RS17645	3864618..3865067	+	450	WP_172422313.1	DUF2384 domain-containing protein	Antitoxin
HHSLTHF2_RS17650	3865064..3865528	+	465	WP_172422314.1	RES family NAD+ phosphorylase	Toxin
HHSLTHF2_RS17655	3865545..3866252	-	708	WP_172422315.1	urea ABC transporter ATP-binding subunit UrtE	-
HHSLTHF2_RS17660	3866252..3867088	-	837	WP_172422316.1	urea ABC transporter ATP-binding protein UrtD	-
HHSLTHF2_RS17665	3867085..3868248	-	1164	WP_172422317.1	urea ABC transporter permease subunit UrtC	-
HHSLTHF2_RS17670	3868252..3869865	-	1614	WP_172422318.1	urea ABC transporter permease subunit UrtB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (7-149)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (96-146)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 16915.16 Da
• Isoelectric Point: 4.1679

>T36575 WP_172422314.1 NZ_AP022843:3865064-3865528 [Halomonas hydrothermalis]
MSEVSAYRLVKRKFQETAFDGEGARLYGGRWNSPGNACVYVASTESLALLEIMVHLESYQLLNAYALLRLTLPTDSILGV
GEADLPDNWREAPAPAETAELGDGWLDSGQSLALAIPSVVVPRELNYMLNPEHPLFDQVITTAEALPFQPDPRL

Nucleotide

• Length: 465 bp

>T36575 NZ_AP022843:3865064-3865528 [Halomonas hydrothermalis]
ATGAGCGAGGTCTCCGCTTATCGGCTGGTTAAGCGTAAATTTCAGGAGACAGCGTTTGATGGCGAAGGTGCACGGCTTTA
TGGCGGGCGTTGGAACAGCCCTGGCAACGCCTGTGTGTATGTGGCAAGCACCGAGTCGCTGGCGCTGCTTGAAATCATGG
TGCATCTGGAAAGCTATCAGCTGCTTAATGCCTATGCGCTGCTGCGCCTGACGCTGCCGACCGATAGCATTCTAGGTGTT
GGGGAAGCCGATCTACCGGATAACTGGCGGGAAGCGCCTGCGCCAGCAGAAACGGCCGAGTTGGGCGACGGCTGGTTGGA
CTCCGGCCAGAGTCTGGCCTTGGCCATTCCCAGCGTAGTCGTGCCAAGAGAGCTCAACTACATGCTCAACCCTGAGCATC
CTCTGTTTGATCAAGTCATCACGACGGCAGAGGCGCTGCCCTTTCAGCCCGACCCACGACTTTGA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16598.13 Da
• Isoelectric Point: 10.1695

>AT36575 WP_172422313.1 NZ_AP022843:3864618-3865067 [Halomonas hydrothermalis]
MDIHFTQYQPPKALASGFWQQIGLPARGRKLHELLHEGVAYRVYPQLAKVSGIEQKALARYVDIPSATLSRRAKSGRFKM
AESDRLYRFAELFKAALDLFEGDAEGARAWLLKPNAGLGGRKPVEMSVTSAEYQTVLNLIGRLEHGVSV

Nucleotide

• Length: 450 bp

>AT36575 NZ_AP022843:3864618-3865067 [Halomonas hydrothermalis]
ATGGATATCCACTTCACCCAATACCAGCCACCTAAAGCCCTAGCATCGGGCTTCTGGCAGCAGATCGGCCTGCCCGCCAG
AGGCCGTAAGCTGCATGAGCTGTTGCATGAAGGCGTGGCGTATCGGGTTTACCCGCAGCTTGCCAAGGTGTCGGGCATCG
AGCAGAAGGCACTGGCGCGCTACGTGGATATTCCCTCTGCCACGCTGAGCCGTCGCGCTAAATCGGGGCGCTTCAAAATG
GCGGAGAGCGACCGATTGTATCGCTTTGCCGAGCTCTTCAAGGCGGCGCTGGATCTGTTCGAGGGTGACGCGGAGGGCGC
GCGTGCTTGGCTGCTCAAGCCCAATGCTGGGCTAGGCGGGCGAAAGCCTGTTGAAATGAGCGTTACATCGGCCGAGTATC
AAACGGTGCTGAACCTGATCGGGCGGCTGGAGCATGGGGTCTCGGTATGA