Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1513042..1513634 Replicon chromosome
Accession NZ_AP022843
Organism Halomonas hydrothermalis strain Slthf2

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HHSLTHF2_RS07210 Protein ID WP_172420527.1
Coordinates 1513341..1513634 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HHSLTHF2_RS07205 Protein ID WP_172420526.1
Coordinates 1513042..1513338 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHSLTHF2_RS07175 1508643..1509665 + 1023 WP_172420520.1 cobalamin biosynthesis protein CobD -
HHSLTHF2_RS07180 1509662..1510777 + 1116 WP_172420521.1 threonine-phosphate decarboxylase -
HHSLTHF2_RS07185 1510761..1511294 + 534 WP_172420522.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -
HHSLTHF2_RS07190 1511291..1512067 + 777 WP_172420523.1 adenosylcobinamide-GDP ribazoletransferase -
HHSLTHF2_RS07195 1512004..1512657 + 654 WP_172420524.1 histidine phosphatase family protein -
HHSLTHF2_RS07200 1512609..1513037 + 429 WP_172420525.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -
HHSLTHF2_RS07205 1513042..1513338 - 297 WP_172420526.1 putative addiction module antidote protein Antitoxin
HHSLTHF2_RS07210 1513341..1513634 - 294 WP_172420527.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHSLTHF2_RS07215 1514070..1515872 + 1803 WP_172420528.1 TonB-dependent receptor -
HHSLTHF2_RS07220 1515862..1516827 + 966 WP_172420529.1 cobalamin-binding protein -
HHSLTHF2_RS07225 1516828..1517823 + 996 WP_172420530.1 iron ABC transporter permease -
HHSLTHF2_RS07230 1517823..1518593 + 771 WP_172420531.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10984.58 Da        Isoelectric Point: 10.3408

>T36573 WP_172420527.1 NZ_AP022843:c1513634-1513341 [Halomonas hydrothermalis]
MADIKQTDTFRKWESKLKDTRAKATIAARIFRLANGLSGDVQPVGQGVSELRIHYGPGYRVYFCQRGDEFILLLCGGNKS
TQQKDIDTAHRLAKAWR

Download         Length: 294 bp

>T36573 NZ_AP022843:c1513634-1513341 [Halomonas hydrothermalis]
ATGGCTGACATAAAGCAGACAGACACTTTCCGGAAGTGGGAAAGCAAGCTCAAAGACACTCGGGCTAAAGCCACGATTGC
CGCGCGCATTTTTCGCTTAGCAAATGGTTTGTCTGGTGATGTTCAGCCAGTCGGGCAAGGCGTCAGTGAGCTGCGCATTC
ATTATGGGCCTGGCTATCGGGTCTACTTTTGTCAGCGCGGTGATGAATTTATTTTACTGCTATGTGGTGGTAATAAGAGT
ACTCAGCAGAAAGATATAGATACGGCTCATCGCCTTGCTAAGGCGTGGAGGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10363.72 Da        Isoelectric Point: 5.0492

>AT36573 WP_172420526.1 NZ_AP022843:c1513338-1513042 [Halomonas hydrothermalis]
MSERLYDYDPAAALDSEAAIAIFLADAFETGDANYIAKAVGVAARAKGMSQLATETGLSREQLYRSFGESGNPTLKTMLA
VTRALGIDITARPHKPAA

Download         Length: 297 bp

>AT36573 NZ_AP022843:c1513338-1513042 [Halomonas hydrothermalis]
ATGAGTGAACGACTTTACGATTATGATCCTGCGGCAGCGCTGGATAGCGAAGCAGCCATTGCGATATTTCTTGCAGATGC
TTTTGAAACCGGTGATGCCAACTACATCGCAAAAGCTGTTGGCGTTGCCGCCAGAGCGAAAGGCATGTCTCAACTAGCGA
CTGAAACGGGATTGTCACGTGAACAGCTTTACCGCTCCTTTGGCGAATCGGGTAACCCAACTCTCAAGACCATGTTAGCG
GTAACCCGGGCGCTGGGGATCGATATCACCGCCCGACCTCATAAACCAGCCGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References