36570

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 634614..636351 Replicon chromosome
Accession NZ_AP022843
Organism Halomonas hydrothermalis strain Slthf2

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag HHSLTHF2_RS03005 Protein ID WP_172419919.1
Coordinates 634614..635261 (+) Length 216 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag HHSLTHF2_RS03010 Protein ID WP_172419920.1
Coordinates 635272..636351 (+) Length 360 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHSLTHF2_RS02995 631148..633157 + 2010 WP_172419917.1 RecQ family ATP-dependent DNA helicase -
HHSLTHF2_RS03000 633162..634388 - 1227 WP_172419918.1 zinc metallochaperone GTPase ZigA -
HHSLTHF2_RS03005 634614..635261 + 648 WP_172419919.1 DUF4433 domain-containing protein Toxin
HHSLTHF2_RS03010 635272..636351 + 1080 WP_172419920.1 macro domain-containing protein Antitoxin
HHSLTHF2_RS03015 636402..636677 - 276 WP_172419921.1 TIGR03643 family protein -
HHSLTHF2_RS03020 636799..637413 - 615 WP_172419922.1 methyltransferase domain-containing protein -
HHSLTHF2_RS03025 637484..638428 - 945 WP_172419923.1 helix-turn-helix domain-containing protein -
HHSLTHF2_RS03030 638759..640174 + 1416 WP_125745557.1 ethanolamine ammonia-lyase subunit EutB -
HHSLTHF2_RS03035 640167..641009 + 843 WP_172419924.1 ethanolamine ammonia-lyase subunit EutC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-215)

Antitoxin

Macro domain

(18-128)


Sequences

Toxin        


Download         Length: 216 a.a.        Molecular weight: 24481.11 Da        Isoelectric Point: 8.8688

>T36570 WP_172419919.1 NZ_AP022843:634614-635261 [Halomonas hydrothermalis]
MAYTNLNPSKALIWRITHRQNLPWIMANGLHAGHSRGKRAAEWVVIGNKELIGRRAHRNVPLAPSGVLNDYVPFYFTPFS
PMMYNIHTGRGGVKTVANRDIVILVSSLHKIAELGLPFVYTDRHAYPVTAHYFNDLGSLSAIDWPLLQQRNFQRDPDDPE
KIERYQAEALIHQYVPIQALLGAICYTPQVQLELQQQAAELGVALDIHCRPSWYF

Download         Length: 648 bp

>T36570 NZ_AP022843:634614-635261 [Halomonas hydrothermalis]
ATGGCATACACGAACCTGAATCCCAGCAAGGCGCTGATTTGGCGGATTACCCATCGCCAGAATCTACCGTGGATTATGGC
GAACGGGCTCCATGCAGGACATAGTCGCGGCAAGCGTGCGGCGGAGTGGGTAGTGATAGGTAATAAAGAGTTAATTGGCC
GCCGTGCGCATCGTAATGTACCGCTGGCACCTAGTGGTGTACTAAACGATTATGTGCCTTTTTACTTCACGCCCTTTTCG
CCAATGATGTACAACATCCACACTGGCCGTGGTGGTGTGAAGACGGTGGCGAACAGAGACATCGTGATTTTGGTCTCCAG
TCTGCATAAAATTGCCGAGTTGGGTTTGCCGTTTGTCTATACTGACCGTCATGCTTATCCGGTCACTGCCCATTACTTTA
ATGACCTAGGCAGTCTGAGCGCTATTGACTGGCCGCTTCTTCAGCAGCGCAACTTCCAGCGTGACCCGGATGACCCTGAG
AAAATTGAGCGTTATCAAGCAGAAGCACTAATTCACCAATATGTGCCCATTCAGGCATTGCTGGGGGCAATATGTTATAC
CCCGCAGGTACAGCTAGAATTACAGCAGCAGGCTGCTGAATTGGGTGTTGCACTAGATATTCACTGTCGACCCAGCTGGT
ATTTTTAA

Antitoxin


Download         Length: 360 a.a.        Molecular weight: 40414.35 Da        Isoelectric Point: 5.3264

>AT36570 WP_172419920.1 NZ_AP022843:635272-636351 [Halomonas hydrothermalis]
MITYTTGNLLNAEVEALVNTVNTVGVMGKGIALMFKERFPANMVAYARACKAGEVQTGHMFVTETDELMGPRWIVNFPTK
QHWRAKSQIQWIIDGLADLRSFIERNQVRSIAIPPLGAGNGGLDWTEIKPYIEQTLGDLQDVEIIVFEPTAKYQNVAKRQ
GVEQLTPARALIAELVRRYWVLGMECSLLEIQKLAWFLERAIDAEGVDNPLDLRFEANSYGPYADRLRHLLNGLDGSYLK
SEKRINDCGPLDTIWFNDAKREKVALYLKTEAKDYLPALEKTAALIDGFESPFGMELLATVDWLLFQSQVNPDPASVMEG
VRNWSGSKSSAQRKLKLFDYSRLELALDRLKSFSTQAAS

Download         Length: 1080 bp

>AT36570 NZ_AP022843:635272-636351 [Halomonas hydrothermalis]
ATGATCACTTACACAACAGGCAACTTGCTGAATGCTGAGGTTGAGGCCCTGGTCAACACCGTTAATACAGTGGGGGTGAT
GGGCAAGGGAATCGCACTGATGTTCAAAGAACGCTTCCCTGCCAATATGGTGGCCTATGCGCGAGCCTGCAAAGCCGGAG
AAGTTCAAACTGGCCATATGTTTGTGACTGAAACCGATGAGTTGATGGGGCCTCGCTGGATCGTCAATTTTCCTACCAAA
CAGCACTGGCGAGCGAAATCTCAGATACAGTGGATTATTGACGGCTTGGCTGATCTGCGCAGTTTTATTGAGCGCAATCA
AGTTCGCTCAATTGCTATTCCGCCTTTGGGGGCTGGTAATGGTGGTTTAGATTGGACTGAGATTAAGCCTTATATCGAGC
AAACGCTGGGAGATTTGCAGGATGTCGAGATTATCGTCTTTGAGCCGACAGCCAAATATCAAAACGTTGCAAAACGTCAG
GGTGTTGAACAGTTAACACCTGCGCGTGCCTTGATCGCTGAATTGGTACGCCGTTACTGGGTACTAGGGATGGAATGCAG
TTTGTTGGAGATACAAAAACTGGCCTGGTTTCTGGAGCGAGCGATTGATGCAGAAGGCGTTGATAATCCGCTGGATCTTC
GGTTCGAAGCTAACAGCTACGGCCCCTATGCCGATCGGCTGCGCCATTTACTTAATGGTTTAGATGGCAGTTATCTCAAA
AGCGAGAAGCGTATCAATGACTGCGGCCCGCTGGATACTATTTGGTTCAATGATGCCAAGCGGGAAAAAGTGGCGCTATA
CCTGAAAACCGAGGCAAAGGATTATCTGCCAGCGCTCGAAAAAACAGCCGCCTTAATTGATGGCTTTGAGTCGCCTTTTG
GGATGGAATTATTAGCCACAGTAGATTGGCTGCTGTTCCAATCGCAGGTTAATCCAGATCCAGCTTCGGTGATGGAAGGC
GTGAGGAATTGGTCAGGCAGTAAAAGTTCGGCACAGCGTAAACTTAAACTGTTTGATTACTCTAGGCTAGAATTAGCACT
TGATCGGCTCAAGAGCTTTTCGACTCAAGCTGCCAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References