Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 28247..28818 Replicon plasmid pTUM19329-2
Accession NZ_AP022841
Organism Legionella sp. TUM19329

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HRS36_RS18490 Protein ID WP_173238596.1
Coordinates 28247..28504 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HRS36_RS18495 Protein ID WP_133137737.1
Coordinates 28498..28818 (+) Length 107 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS36_RS18480 24404..25327 + 924 WP_173238594.1 tyrosine-type recombinase/integrase -
HRS36_RS18485 25311..28181 + 2871 WP_173238595.1 Tn3 family transposase -
HRS36_RS18490 28247..28504 + 258 WP_173238596.1 type II toxin-antitoxin system HicA family toxin Toxin
HRS36_RS18495 28498..28818 + 321 WP_133137737.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HRS36_RS18500 28918..29313 - 396 WP_173238716.1 hypothetical protein -
HRS36_RS18505 29548..30105 + 558 WP_173238717.1 hypothetical protein -
HRS36_RS18510 30165..30563 - 399 WP_173238718.1 hypothetical protein -
HRS36_RS18515 30538..31965 + 1428 WP_173238719.1 hypothetical protein -
HRS36_RS18520 32096..33103 - 1008 WP_173238720.1 ParA family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..35454 35454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(23-82)

Antitoxin

(52-102)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9395.07 Da        Isoelectric Point: 10.8668

>T36568 WP_173238596.1 NZ_AP022841:28247-28504 [Legionella sp. TUM19329]
MKAKHKKVLHSIFETPVNASIIWKDIESLLVSLGAELSEGRGSRVRIALNGVRAVFHRPHPKKEADKGAVVSMRRLLKEA
GVEPC

Download         Length: 258 bp

>T36568 NZ_AP022841:28247-28504 [Legionella sp. TUM19329]
ATGAAAGCTAAACATAAAAAAGTGCTGCACAGCATATTTGAAACGCCAGTGAATGCCAGCATTATCTGGAAGGATATCGA
GTCGTTGCTTGTTAGCTTGGGCGCTGAATTATCCGAGGGGCGCGGATCACGAGTACGTATAGCGCTGAATGGTGTTCGGG
CTGTTTTTCATCGACCTCATCCTAAAAAAGAGGCCGATAAGGGAGCAGTTGTTTCAATGAGGCGTTTACTGAAAGAAGCA
GGAGTAGAGCCATGTTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12145.64 Da        Isoelectric Point: 5.1529

>AT36568 WP_133137737.1 NZ_AP022841:28498-28818 [Legionella sp. TUM19329]
MLNYKGYLGHVEFDDENELFVGEVINTKDVITFQADTAHGLKQAFVESIDDYIDFCHERNEKPEKPFSGKFNLRISPELH
REAYVAAKHSGMSLNSWVCDVLKHAV

Download         Length: 321 bp

>AT36568 NZ_AP022841:28498-28818 [Legionella sp. TUM19329]
ATGTTAAATTATAAAGGTTATCTTGGTCATGTAGAGTTTGATGATGAAAATGAACTCTTTGTTGGCGAAGTCATTAATAC
CAAAGATGTCATTACGTTCCAGGCTGATACAGCGCATGGGCTAAAACAGGCATTTGTTGAGTCAATAGATGATTATATTG
ACTTTTGTCATGAGCGAAATGAAAAACCAGAAAAACCGTTTTCAGGGAAATTCAATCTGAGAATTTCTCCAGAGCTCCAT
CGTGAGGCCTATGTAGCAGCCAAACATTCTGGCATGAGCCTAAACTCATGGGTGTGTGATGTGTTGAAGCATGCTGTTTA
A

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References