Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/ParE-CC2985
Location 134056..134596 Replicon plasmid pTUM19329-1
Accession NZ_AP022840
Organism Legionella sp. TUM19329

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag HRS36_RS18305 Protein ID WP_173238684.1
Coordinates 134300..134596 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID -
Locus tag HRS36_RS18300 Protein ID WP_173238683.1
Coordinates 134056..134310 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS36_RS18275 130597..131574 - 978 WP_173238678.1 recombination-associated protein RdgC -
HRS36_RS18280 131584..132033 - 450 WP_173238679.1 single-stranded DNA-binding protein -
HRS36_RS18285 132049..132327 - 279 WP_173238680.1 HU family DNA-binding protein -
HRS36_RS18290 132490..132960 - 471 WP_173238681.1 WGR domain-containing protein -
HRS36_RS18295 132957..133844 - 888 WP_173238682.1 recombinase family protein -
HRS36_RS18300 134056..134310 + 255 WP_173238683.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HRS36_RS18305 134300..134596 + 297 WP_173238684.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRS36_RS18310 134798..136297 - 1500 WP_173238685.1 DUF3987 domain-containing protein -
HRS36_RS18315 136441..136821 + 381 WP_173238686.1 nucleoside triphosphate hydrolase -
HRS36_RS18320 137080..139575 - 2496 WP_173238687.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..140878 140878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(4-75)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11496.19 Da        Isoelectric Point: 7.3533

>T36567 WP_173238684.1 NZ_AP022840:134300-134596 [Legionella sp. TUM19329]
MPNKSYRLYPKAIEDLESIYSYSISEFGIKRTEDYILAIETSFQHLAEDPLISRACDYVRQNLRVFNIGSHIIFFKITSY
GIAVIRVLHQSMDFGRHF

Download         Length: 297 bp

>T36567 NZ_AP022840:134300-134596 [Legionella sp. TUM19329]
ATGCCAAATAAAAGTTATCGTCTTTATCCAAAGGCTATAGAGGATCTTGAGTCCATCTATTCATATAGTATAAGTGAATT
TGGTATTAAACGGACAGAAGATTATATTTTGGCGATCGAAACCAGTTTCCAACATCTTGCAGAAGATCCGTTGATTTCGC
GCGCATGTGATTATGTTCGCCAGAATTTGAGGGTATTTAATATCGGTTCCCATATTATTTTCTTTAAAATTACAAGTTAT
GGTATCGCAGTCATTCGAGTGTTGCATCAATCTATGGATTTTGGCAGACACTTTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9678.97 Da        Isoelectric Point: 5.6334

>AT36567 WP_173238683.1 NZ_AP022840:134056-134310 [Legionella sp. TUM19329]
MARTMTVDLGSELRDYVQFLVESGDYRSNSEVLRESLRLLREKQAASKLEQLRHLIDEGEGSGDPLMWNAHDFLECMKKT
PHAK

Download         Length: 255 bp

>AT36567 NZ_AP022840:134056-134310 [Legionella sp. TUM19329]
ATGGCTCGCACAATGACGGTTGATTTGGGCAGTGAACTTCGTGATTATGTTCAATTTCTTGTTGAGTCTGGGGATTATAG
AAGTAATAGTGAAGTTTTGAGAGAGTCTCTGCGCCTGCTTCGTGAAAAACAAGCGGCTTCAAAGCTCGAACAGTTGCGTC
ATCTTATTGATGAAGGAGAGGGTAGTGGCGATCCCTTAATGTGGAATGCACATGATTTTCTTGAGTGCATGAAGAAAACA
CCTCATGCCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References