Detailed information of TA system TA036567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/ParE-CC2985
• Location: 134056..134596
• Replicon: plasmid pTUM19329-1
• Accession: NZ_AP022840
• Organism: Legionella sp. TUM19329

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: -
• Locus tag: HRS36_RS18305
• Protein ID: WP_173238684.1
• Coordinates: 134300..134596 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: HRS36_RS18300
• Protein ID: WP_173238683.1
• Coordinates: 134056..134310 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRS36_RS18275	130597..131574	-	978	WP_173238678.1	recombination-associated protein RdgC	-
HRS36_RS18280	131584..132033	-	450	WP_173238679.1	single-stranded DNA-binding protein	-
HRS36_RS18285	132049..132327	-	279	WP_173238680.1	HU family DNA-binding protein	-
HRS36_RS18290	132490..132960	-	471	WP_173238681.1	WGR domain-containing protein	-
HRS36_RS18295	132957..133844	-	888	WP_173238682.1	recombinase family protein	-
HRS36_RS18300	134056..134310	+	255	WP_173238683.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HRS36_RS18305	134300..134596	+	297	WP_173238684.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HRS36_RS18310	134798..136297	-	1500	WP_173238685.1	DUF3987 domain-containing protein	-
HRS36_RS18315	136441..136821	+	381	WP_173238686.1	nucleoside triphosphate hydrolase	-
HRS36_RS18320	137080..139575	-	2496	WP_173238687.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..140878	140878

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (4-75)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11496.19 Da
• Isoelectric Point: 7.3533

>T36567 WP_173238684.1 NZ_AP022840:134300-134596 [Legionella sp. TUM19329]
MPNKSYRLYPKAIEDLESIYSYSISEFGIKRTEDYILAIETSFQHLAEDPLISRACDYVRQNLRVFNIGSHIIFFKITSY
GIAVIRVLHQSMDFGRHF

Nucleotide

• Length: 297 bp

>T36567 NZ_AP022840:134300-134596 [Legionella sp. TUM19329]
ATGCCAAATAAAAGTTATCGTCTTTATCCAAAGGCTATAGAGGATCTTGAGTCCATCTATTCATATAGTATAAGTGAATT
TGGTATTAAACGGACAGAAGATTATATTTTGGCGATCGAAACCAGTTTCCAACATCTTGCAGAAGATCCGTTGATTTCGC
GCGCATGTGATTATGTTCGCCAGAATTTGAGGGTATTTAATATCGGTTCCCATATTATTTTCTTTAAAATTACAAGTTAT
GGTATCGCAGTCATTCGAGTGTTGCATCAATCTATGGATTTTGGCAGACACTTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9678.97 Da
• Isoelectric Point: 5.6334

>AT36567 WP_173238683.1 NZ_AP022840:134056-134310 [Legionella sp. TUM19329]
MARTMTVDLGSELRDYVQFLVESGDYRSNSEVLRESLRLLREKQAASKLEQLRHLIDEGEGSGDPLMWNAHDFLECMKKT
PHAK

Nucleotide

• Length: 255 bp

>AT36567 NZ_AP022840:134056-134310 [Legionella sp. TUM19329]
ATGGCTCGCACAATGACGGTTGATTTGGGCAGTGAACTTCGTGATTATGTTCAATTTCTTGTTGAGTCTGGGGATTATAG
AAGTAATAGTGAAGTTTTGAGAGAGTCTCTGCGCCTGCTTCGTGAAAAACAAGCGGCTTCAAAGCTCGAACAGTTGCGTC
ATCTTATTGATGAAGGAGAGGGTAGTGGCGATCCCTTAATGTGGAATGCACATGATTTTCTTGAGTGCATGAAGAAAACA
CCTCATGCCAAATAA