Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/ParE-CC2985
Location 54193..54733 Replicon plasmid pTUM19329-1
Accession NZ_AP022840
Organism Legionella sp. TUM19329

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag HRS36_RS17890 Protein ID WP_173238616.1
Coordinates 54437..54733 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID -
Locus tag HRS36_RS17885 Protein ID WP_173238615.1
Coordinates 54193..54447 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS36_RS17860 49883..50149 - 267 WP_173238612.1 type II toxin-antitoxin system RelE/ParE family toxin -
HRS36_RS17865 50133..50345 - 213 WP_173238613.1 ribbon-helix-helix domain-containing protein -
HRS36_RS17870 50841..51977 - 1137 Protein_50 IS91 family transposase -
HRS36_RS17875 51981..52835 - 855 WP_173238370.1 site-specific integrase -
HRS36_RS17880 53047..54069 + 1023 WP_173238614.1 tyrosine-type recombinase/integrase -
HRS36_RS17885 54193..54447 + 255 WP_173238615.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HRS36_RS17890 54437..54733 + 297 WP_173238616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRS36_RS17895 55054..56193 - 1140 WP_173238617.1 DUF3987 domain-containing protein -
HRS36_RS17900 56336..57883 + 1548 WP_173235442.1 IS21 family transposase -
HRS36_RS17905 57876..58631 + 756 WP_173235440.1 IS21-like element helper ATPase IstB -
HRS36_RS17910 58682..59077 - 396 WP_173238618.1 DUF3987 domain-containing protein -
HRS36_RS17915 59231..59611 + 381 WP_173238619.1 nucleoside triphosphate hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..140878 140878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11586.23 Da        Isoelectric Point: 7.3524

>T36566 WP_173238616.1 NZ_AP022840:54437-54733 [Legionella sp. TUM19329]
MPNKTYRLYPKAIEDLESIYLYSTREFGIKRTEDYILAIETSFQHLTDDPLISRVCDYVRQDLRAFNTGSHVIYFKITSY
GIGVIRVLHQSMDFGRHF

Download         Length: 297 bp

>T36566 NZ_AP022840:54437-54733 [Legionella sp. TUM19329]
ATGCCAAATAAAACATATCGCCTTTATCCCAAGGCTATTGAAGATCTTGAGTCTATCTATTTATATAGTACGCGCGAATT
TGGCATTAAAAGAACAGAAGATTATATTTTGGCGATCGAAACCAGTTTCCAACATCTTACTGATGATCCTTTGATTTCTC
GAGTATGTGATTATGTTCGTCAGGATTTAAGGGCATTTAATACCGGTTCACATGTAATTTATTTCAAAATCACAAGTTAT
GGTATCGGAGTTATTCGGGTGTTGCATCAATCTATGGATTTTGGCAGGCACTTTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9723.01 Da        Isoelectric Point: 5.7316

>AT36566 WP_173238615.1 NZ_AP022840:54193-54447 [Legionella sp. TUM19329]
MARTMTVDLGSELRDYVQFLVDSGDYRSNSEVLRESLRLLREKQAGSKLEQLRHLIDEGEGSGEPLMWNAQEFLERMKKT
PHAK

Download         Length: 255 bp

>AT36566 NZ_AP022840:54193-54447 [Legionella sp. TUM19329]
ATGGCTCGCACAATGACCGTTGATTTGGGTAGTGAACTTCGTGATTATGTTCAGTTTCTTGTTGATTCAGGTGATTATAG
AAGTAATAGCGAAGTACTAAGAGAATCGTTGCGTCTGCTACGTGAAAAACAAGCCGGATCAAAACTTGAGCAGTTGCGTC
ATCTTATCGATGAAGGGGAAGGAAGCGGTGAACCCCTAATGTGGAATGCGCAGGAATTTCTCGAGCGAATGAAGAAAACT
CCCCATGCCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References