Detailed information of TA system TA036566

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/ParE-CC2985
• Location: 54193..54733
• Replicon: plasmid pTUM19329-1
• Accession: NZ_AP022840
• Organism: Legionella sp. TUM19329

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: -
• Locus tag: HRS36_RS17890
• Protein ID: WP_173238616.1
• Coordinates: 54437..54733 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: HRS36_RS17885
• Protein ID: WP_173238615.1
• Coordinates: 54193..54447 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRS36_RS17860	49883..50149	-	267	WP_173238612.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HRS36_RS17865	50133..50345	-	213	WP_173238613.1	ribbon-helix-helix domain-containing protein	-
HRS36_RS17870	50841..51977	-	1137	Protein_50	IS91 family transposase	-
HRS36_RS17875	51981..52835	-	855	WP_173238370.1	site-specific integrase	-
HRS36_RS17880	53047..54069	+	1023	WP_173238614.1	tyrosine-type recombinase/integrase	-
HRS36_RS17885	54193..54447	+	255	WP_173238615.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HRS36_RS17890	54437..54733	+	297	WP_173238616.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HRS36_RS17895	55054..56193	-	1140	WP_173238617.1	DUF3987 domain-containing protein	-
HRS36_RS17900	56336..57883	+	1548	WP_173235442.1	IS21 family transposase	-
HRS36_RS17905	57876..58631	+	756	WP_173235440.1	IS21-like element helper ATPase IstB	-
HRS36_RS17910	58682..59077	-	396	WP_173238618.1	DUF3987 domain-containing protein	-
HRS36_RS17915	59231..59611	+	381	WP_173238619.1	nucleoside triphosphate hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..140878	140878

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11586.23 Da
• Isoelectric Point: 7.3524

>T36566 WP_173238616.1 NZ_AP022840:54437-54733 [Legionella sp. TUM19329]
MPNKTYRLYPKAIEDLESIYLYSTREFGIKRTEDYILAIETSFQHLTDDPLISRVCDYVRQDLRAFNTGSHVIYFKITSY
GIGVIRVLHQSMDFGRHF

Nucleotide

• Length: 297 bp

>T36566 NZ_AP022840:54437-54733 [Legionella sp. TUM19329]
ATGCCAAATAAAACATATCGCCTTTATCCCAAGGCTATTGAAGATCTTGAGTCTATCTATTTATATAGTACGCGCGAATT
TGGCATTAAAAGAACAGAAGATTATATTTTGGCGATCGAAACCAGTTTCCAACATCTTACTGATGATCCTTTGATTTCTC
GAGTATGTGATTATGTTCGTCAGGATTTAAGGGCATTTAATACCGGTTCACATGTAATTTATTTCAAAATCACAAGTTAT
GGTATCGGAGTTATTCGGGTGTTGCATCAATCTATGGATTTTGGCAGGCACTTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9723.01 Da
• Isoelectric Point: 5.7316

>AT36566 WP_173238615.1 NZ_AP022840:54193-54447 [Legionella sp. TUM19329]
MARTMTVDLGSELRDYVQFLVDSGDYRSNSEVLRESLRLLREKQAGSKLEQLRHLIDEGEGSGEPLMWNAQEFLERMKKT
PHAK

Nucleotide

• Length: 255 bp

>AT36566 NZ_AP022840:54193-54447 [Legionella sp. TUM19329]
ATGGCTCGCACAATGACCGTTGATTTGGGTAGTGAACTTCGTGATTATGTTCAGTTTCTTGTTGATTCAGGTGATTATAG
AAGTAATAGCGAAGTACTAAGAGAATCGTTGCGTCTGCTACGTGAAAAACAAGCCGGATCAAAACTTGAGCAGTTGCGTC
ATCTTATCGATGAAGGGGAAGGAAGCGGTGAACCCCTAATGTGGAATGCGCAGGAATTTCTCGAGCGAATGAAGAAAACT
CCCCATGCCAAATAA