Detailed information of TA system TA036564

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 33431..33962
• Replicon: plasmid pTUM19329-1
• Accession: NZ_AP022840
• Organism: Legionella sp. TUM19329

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HRS36_RS17790
• Protein ID: WP_173238602.1
• Coordinates: 33681..33962 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: G9ER77
• Locus tag: HRS36_RS17785
• Protein ID: WP_006871683.1
• Coordinates: 33431..33694 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRS36_RS17765	30234..31157	-	924	WP_173238594.1	tyrosine-type recombinase/integrase	-
HRS36_RS17770	31416..31592	+	177	WP_173238103.1	ATP-binding protein	-
HRS36_RS17775	31643..31930	-	288	WP_173238600.1	hypothetical protein	-
HRS36_RS17780	32111..33391	+	1281	WP_173238601.1	Tn3 family transposase	-
HRS36_RS17785	33431..33694	+	264	WP_006871683.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HRS36_RS17790	33681..33962	+	282	WP_173238602.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HRS36_RS17795	34080..34268	+	189	WP_173238691.1	hypothetical protein	-
HRS36_RS17800	34481..35785	-	1305	WP_173238603.1	hypothetical protein	-
HRS36_RS17805	35785..36834	-	1050	WP_173238604.1	ParA family protein	-
HRS36_RS17810	37555..38439	+	885	WP_173238605.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..140878	140878

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10953.63 Da
• Isoelectric Point: 9.8103

>T36564 WP_173238602.1 NZ_AP022840:33681-33962 [Legionella sp. TUM19329]
MRGIEKTTQFKKDYKREKKGKYREVLETLFVKVLVALANDNELAEKHRDHALTNNWSDHRDCHIKPDLILIYRKPDINTL
QLVRLGSHSELGI

Nucleotide

• Length: 282 bp

>T36564 NZ_AP022840:33681-33962 [Legionella sp. TUM19329]
ATGCGGGGGATTGAAAAAACCACTCAATTTAAAAAAGACTACAAACGTGAAAAGAAGGGAAAATATAGAGAGGTTTTAGA
AACTCTCTTTGTTAAGGTGTTGGTAGCTCTTGCAAATGATAATGAATTAGCAGAAAAGCACCGCGACCATGCTCTTACTA
ATAACTGGAGTGATCATCGTGACTGCCACATTAAGCCTGATTTAATTCTTATCTATAGAAAACCAGATATAAATACGTTG
CAACTAGTTCGACTTGGTTCGCATAGTGAACTTGGTATTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9484.98 Da
• Isoelectric Point: 8.7689

>AT36564 WP_006871683.1 NZ_AP022840:33431-33694 [Legionella sp. TUM19329]
MTANAVVRARIDGHIKEEASAVLASMGLTVSDAFRLLLTRVASEKALPFEPLVPNQKTIEAMKEARRGKLRSFKSIDSLM
DDLNAGD

Nucleotide

• Length: 264 bp

>AT36564 NZ_AP022840:33431-33694 [Legionella sp. TUM19329]
ATGACTGCAAATGCGGTTGTTCGAGCTAGAATCGATGGGCATATTAAAGAAGAGGCTTCTGCTGTGTTGGCCTCAATGGG
GTTAACGGTATCTGATGCATTTCGTCTCTTATTGACACGTGTGGCGAGTGAAAAGGCTTTACCATTTGAACCTCTAGTAC
CCAATCAAAAAACAATTGAGGCTATGAAAGAGGCTCGAAGAGGTAAGTTACGCTCATTCAAAAGTATTGATTCTCTAATG
GATGATTTAAATGCGGGGGATTGA

Structures

Antitoxin

• AlphaFold DB: G9ER77