Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 17712..18283 Replicon plasmid pTUM19329-1
Accession NZ_AP022840
Organism Legionella sp. TUM19329

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HRS36_RS17695 Protein ID WP_173238596.1
Coordinates 17712..17969 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HRS36_RS17700 Protein ID WP_133137737.1
Coordinates 17963..18283 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS36_RS17685 13869..14792 + 924 WP_173238594.1 tyrosine-type recombinase/integrase -
HRS36_RS17690 14776..17646 + 2871 WP_173238595.1 Tn3 family transposase -
HRS36_RS17695 17712..17969 + 258 WP_173238596.1 type II toxin-antitoxin system HicA family toxin Toxin
HRS36_RS17700 17963..18283 + 321 WP_133137737.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HRS36_RS17705 18387..19529 - 1143 WP_173238597.1 hypothetical protein -
HRS36_RS17710 19690..20064 + 375 WP_173238598.1 ThiF family adenylyltransferase -
HRS36_RS17715 20288..21133 - 846 WP_173235473.1 IS3 family transposase -
HRS36_RS17720 21123..21407 - 285 WP_173235475.1 transposase -
HRS36_RS17725 21384..21638 + 255 WP_173238690.1 ThiF family adenylyltransferase -
HRS36_RS17730 21689..22426 - 738 WP_173236264.1 IS21-like element helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..140878 140878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9395.07 Da        Isoelectric Point: 10.8668

>T36562 WP_173238596.1 NZ_AP022840:17712-17969 [Legionella sp. TUM19329]
MKAKHKKVLHSIFETPVNASIIWKDIESLLVSLGAELSEGRGSRVRIALNGVRAVFHRPHPKKEADKGAVVSMRRLLKEA
GVEPC

Download         Length: 258 bp

>T36562 NZ_AP022840:17712-17969 [Legionella sp. TUM19329]
ATGAAAGCTAAACATAAAAAAGTGCTGCACAGCATATTTGAAACGCCAGTGAATGCCAGCATTATCTGGAAGGATATCGA
GTCGTTGCTTGTTAGCTTGGGCGCTGAATTATCCGAGGGGCGCGGATCACGAGTACGTATAGCGCTGAATGGTGTTCGGG
CTGTTTTTCATCGACCTCATCCTAAAAAAGAGGCCGATAAGGGAGCAGTTGTTTCAATGAGGCGTTTACTGAAAGAAGCA
GGAGTAGAGCCATGTTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12145.64 Da        Isoelectric Point: 5.1529

>AT36562 WP_133137737.1 NZ_AP022840:17963-18283 [Legionella sp. TUM19329]
MLNYKGYLGHVEFDDENELFVGEVINTKDVITFQADTAHGLKQAFVESIDDYIDFCHERNEKPEKPFSGKFNLRISPELH
REAYVAAKHSGMSLNSWVCDVLKHAV

Download         Length: 321 bp

>AT36562 NZ_AP022840:17963-18283 [Legionella sp. TUM19329]
ATGTTAAATTATAAAGGTTATCTTGGTCATGTAGAGTTTGATGATGAAAATGAACTCTTTGTTGGCGAAGTCATTAATAC
CAAAGATGTCATTACGTTCCAGGCTGATACAGCGCATGGGCTAAAACAGGCATTTGTTGAGTCAATAGATGATTATATTG
ACTTTTGTCATGAGCGAAATGAAAAACCAGAAAAACCGTTTTCAGGGAAATTCAATCTGAGAATTTCTCCAGAGCTCCAT
CGTGAGGCCTATGTAGCAGCCAAACATTCTGGCATGAGCCTAAACTCATGGGTGTGTGATGTGTTGAAGCATGCTGTTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References