Detailed information of TA system TA036561

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/ParE-CC2985
• Location: 67753..68293
• Replicon: chromosome
• Accession: NZ_AP022839
• Organism: Legionella sp. TUM19329

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: -
• Locus tag: HRS36_RS00370
• Protein ID: WP_173235516.1
• Coordinates: 67753..68049 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: A0A6F8SZ84
• Locus tag: HRS36_RS00375
• Protein ID: WP_021460206.1
• Coordinates: 68039..68293 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRS36_RS00345	63105..63329	-	225	WP_173235509.1	hypothetical protein	-
HRS36_RS00350	63806..64723	+	918	WP_173235511.1	IS21 family transposase	-
HRS36_RS00355	65033..65614	+	582	WP_173235513.1	hypothetical protein	-
HRS36_RS00360	65607..66362	+	756	WP_173235440.1	IS21-like element helper ATPase IstB	-
HRS36_RS00365	66490..67623	+	1134	WP_173235515.1	hypothetical protein	-
HRS36_RS00370	67753..68049	-	297	WP_173235516.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HRS36_RS00375	68039..68293	-	255	WP_021460206.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HRS36_RS00380	68504..69391	+	888	WP_173235518.1	recombinase family protein	-
HRS36_RS00385	69388..69789	+	402	WP_173235520.1	WGR domain-containing protein	-
HRS36_RS00390	69958..70233	+	276	WP_173235522.1	HU family DNA-binding protein	-
HRS36_RS00395	70411..70983	+	573	WP_173235524.1	hypothetical protein	-
HRS36_RS00400	70976..71515	+	540	WP_173235526.1	hypothetical protein	-
HRS36_RS00405	71778..72569	-	792	WP_173235528.1	phosphotransferase	-
HRS36_RS00410	72569..73126	-	558	WP_173235530.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	22693..122490	99797

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (4-75)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11679.38 Da
• Isoelectric Point: 7.4168

>T36561 WP_173235516.1 NZ_AP022839:c68049-67753 [Legionella sp. TUM19329]
MPNKTYRLYPKAIEDLESIYLYSTREFGIKRTEDYILAIETSFQHLADDPLISRTCDYVRQDLRAFNVGSHVIFFKMTHY
GIAVIRVLHQSMDFNRHF

Nucleotide

• Length: 297 bp

>T36561 NZ_AP022839:c68049-67753 [Legionella sp. TUM19329]
ATGCCAAATAAAACATATCGTCTTTATCCAAAGGCTATAGAGGATCTTGAGTCAATCTATTTATATAGTACGCGCGAATT
TGGTATAAAAAGAACAGAAGATTATATTTTGGCAATTGAAACAAGCTTCCAACATCTTGCAGATGATCCACTTATTTCTC
GAACATGTGATTATGTCCGTCAGGATTTGAGGGCTTTCAATGTAGGTTCTCATGTTATTTTTTTCAAAATGACTCATTAT
GGTATTGCAGTTATTCGGGTGTTGCATCAATCTATGGATTTTAATAGACACTTTTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9780.06 Da
• Isoelectric Point: 4.9108

>AT36561 WP_021460206.1 NZ_AP022839:c68293-68039 [Legionella sp. TUM19329]
MARTMTVDLGSELRDYVQFLVDSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGEGSGDPLMWNAEEFLERMKKV
PHAK

Nucleotide

• Length: 255 bp

>AT36561 NZ_AP022839:c68293-68039 [Legionella sp. TUM19329]
ATGGCTCGCACAATGACTGTTGATTTGGGTAGTGAACTTCGTGATTATGTTCAGTTTCTTGTTGATTCAGGTGATTATAG
AAGTAATAGTGAAGTATTAAGAGAATCATTGCGTCTGCTTCGTGAAAAACAAGCTGAATCAAAGCTTGAGCAGTTACGTC
ATCTTATCGATGAAGGGGAAGGGAGCGGCGATCCATTAATGTGGAACGCGGAAGAATTTCTTGAGCGAATGAAGAAAGTC
CCCCATGCCAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A6F8SZ84