Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 2814442..2815016 Replicon chromosome
Accession NZ_AP022829
Organism Adlercreutzia sp. 8CFCBH1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HRR28_RS11990 Protein ID WP_173114814.1
Coordinates 2814442..2814747 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HRR28_RS11995 Protein ID WP_173115424.1
Coordinates 2814744..2815016 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR28_RS11960 2809539..2810189 - 651 WP_173114801.1 HAD-IA family hydrolase -
HRR28_RS11965 2810310..2811278 + 969 WP_173114803.1 glutaminase A -
HRR28_RS11970 2811342..2812094 + 753 WP_173114805.1 NAD-dependent protein deacylase -
HRR28_RS11975 2812112..2812528 + 417 WP_173114808.1 hypothetical protein -
HRR28_RS11980 2812596..2813522 - 927 WP_173114810.1 restriction endonuclease -
HRR28_RS11985 2813642..2814259 - 618 WP_173114812.1 restriction endonuclease subunit S -
HRR28_RS11990 2814442..2814747 - 306 WP_173114814.1 type II toxin-antitoxin system YafQ family toxin Toxin
HRR28_RS11995 2814744..2815016 - 273 WP_173115424.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HRR28_RS12000 2815114..2816082 + 969 WP_173114816.1 tyrosine-type recombinase/integrase -
HRR28_RS12005 2816145..2816996 + 852 WP_173114818.1 hypothetical protein -
HRR28_RS12010 2816993..2817496 + 504 WP_173114821.1 restriction endonuclease subunit S -
HRR28_RS12015 2817462..2818649 - 1188 WP_197745956.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2801036..2838271 37235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11703.24 Da        Isoelectric Point: 6.9691

>T36560 WP_173114814.1 NZ_AP022829:c2814747-2814442 [Adlercreutzia sp. 8CFCBH1]
MSARLEAKFAPAFSRDLKRKARKREWDLAELEAVIGLILENSTESIEILKHRHNMHRLSGRWEGSNECHVANAGDWLLIW
CVDGDTAYLQRTGSHDELFRQ

Download         Length: 306 bp

>T36560 NZ_AP022829:c2814747-2814442 [Adlercreutzia sp. 8CFCBH1]
ATGAGCGCGCGACTTGAAGCGAAGTTTGCCCCAGCATTTAGCCGAGATTTAAAAAGGAAAGCTCGTAAGCGAGAGTGGGA
TCTTGCTGAGCTAGAAGCAGTCATTGGTCTTATCTTGGAAAACAGCACCGAATCCATCGAGATCCTCAAACACAGACACA
ATATGCATAGGCTTTCGGGCAGATGGGAAGGAAGCAATGAATGCCATGTTGCCAATGCCGGCGATTGGCTTCTCATCTGG
TGCGTAGATGGCGATACAGCCTACCTTCAACGCACTGGCTCCCATGACGAACTGTTCCGACAGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9854.02 Da        Isoelectric Point: 4.2542

>AT36560 WP_173115424.1 NZ_AP022829:c2815016-2814744 [Adlercreutzia sp. 8CFCBH1]
MAASTLTIRLDSNLKDEASRVVEHYGLDISTAMRAFLTQIVNTNAIPLSLDYEQPNEESLIAIRETKEMITNGSGESYSN
AHDLIQAALA

Download         Length: 273 bp

>AT36560 NZ_AP022829:c2815016-2814744 [Adlercreutzia sp. 8CFCBH1]
ATGGCTGCCAGCACTTTGACGATTCGCCTTGATAGCAACTTGAAGGACGAGGCTTCCAGGGTTGTCGAGCACTACGGCCT
TGATATTTCTACGGCTATGCGAGCATTCTTGACGCAGATTGTGAATACCAATGCAATTCCTCTCTCGCTTGATTACGAAC
AGCCGAATGAGGAGAGTCTGATTGCCATACGCGAGACGAAGGAGATGATTACTAACGGATCGGGCGAGAGCTACAGCAAC
GCTCACGATCTGATTCAGGCGGCTTTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References