Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2067073..2067661 Replicon chromosome
Accession NZ_AP022829
Organism Adlercreutzia sp. 8CFCBH1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HRR28_RS08825 Protein ID WP_197745940.1
Coordinates 2067353..2067661 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HRR28_RS08820 Protein ID WP_173113772.1
Coordinates 2067073..2067360 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR28_RS08795 2062334..2062504 - 171 WP_173113760.1 hypothetical protein -
HRR28_RS08800 2063061..2063291 + 231 WP_173113763.1 hypothetical protein -
HRR28_RS08805 2064140..2065273 + 1134 WP_197745939.1 CDP-glycerol glycerophosphotransferase family protein -
HRR28_RS08810 2065285..2066034 - 750 WP_173113766.1 ABC transporter ATP-binding protein -
HRR28_RS08815 2066024..2066851 - 828 WP_173113769.1 ABC transporter permease -
HRR28_RS08820 2067073..2067360 - 288 WP_173113772.1 putative addiction module antidote protein Antitoxin
HRR28_RS08825 2067353..2067661 - 309 WP_197745940.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRR28_RS08830 2067872..2070784 - 2913 WP_173113775.1 DEAD/DEAH box helicase family protein -
HRR28_RS08835 2070872..2072017 - 1146 WP_173113778.1 undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cps4I 2014792..2070868 56076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(7-91)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11684.51 Da        Isoelectric Point: 10.3494

>T36558 WP_197745940.1 NZ_AP022829:c2067661-2067353 [Adlercreutzia sp. 8CFCBH1]
VRIVKSPRYEKWASSLRDRNVIARINARILQIKHYGALTGDWKAVGDGVFELRFHFGAGYRVYIALEGAALLLLLVGGTK
SSQTKDIKLAKEIYESWRRDYE

Download         Length: 309 bp

>T36558 NZ_AP022829:c2067661-2067353 [Adlercreutzia sp. 8CFCBH1]
GTGAGGATTGTCAAATCTCCGCGTTATGAGAAATGGGCGTCTTCTCTCAGGGATCGCAATGTGATCGCGCGTATCAATGC
GCGGATCCTTCAGATCAAGCACTATGGGGCATTGACGGGGGATTGGAAAGCGGTAGGCGATGGAGTATTCGAGTTGAGAT
TTCATTTCGGAGCTGGATATCGCGTCTATATCGCCCTTGAAGGCGCAGCCCTCCTCCTGCTGCTCGTTGGAGGCACGAAG
TCGTCTCAAACGAAGGACATTAAACTCGCCAAGGAGATCTACGAGTCGTGGAGGCGTGACTATGAGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10163.57 Da        Isoelectric Point: 4.2412

>AT36558 WP_173113772.1 NZ_AP022829:c2067360-2067073 [Adlercreutzia sp. 8CFCBH1]
MSSEWIEWDPSLDVNSSEDVAAFLNAVLELGDPAILPDALGVIARSRGMKAIAEETGLGRESLYKSLSKSGNPRFSTVVN
VLDCLGFRLQVVPAA

Download         Length: 288 bp

>AT36558 NZ_AP022829:c2067360-2067073 [Adlercreutzia sp. 8CFCBH1]
ATGAGTAGCGAATGGATAGAATGGGATCCATCGTTGGATGTTAATTCCAGCGAGGACGTTGCCGCGTTTCTCAATGCCGT
CCTAGAGCTGGGGGATCCAGCGATTCTGCCAGATGCGCTCGGCGTTATCGCCCGATCGCGCGGCATGAAGGCTATTGCCG
AGGAAACGGGCCTCGGACGCGAGAGCCTCTATAAATCGCTGAGCAAATCGGGCAACCCTCGCTTCAGCACTGTTGTTAAT
GTGCTTGATTGCCTTGGATTCAGGCTTCAAGTCGTGCCTGCCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References