Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 1595079..1595538 Replicon chromosome
Accession NZ_AP022826
Organism Nitratiruptor labii strain HRV44

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NIL_RS08025 Protein ID WP_187647260.1
Coordinates 1595079..1595336 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag NIL_RS08030 Protein ID WP_187647261.1
Coordinates 1595329..1595538 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL_RS07985 1590482..1591456 - 975 WP_187647252.1 porphobilinogen synthase -
NIL_RS07990 1591509..1592072 + 564 WP_187647253.1 GTP cyclohydrolase II -
NIL_RS07995 1592069..1592641 + 573 WP_187647254.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
NIL_RS08000 1592642..1592866 + 225 WP_187647255.1 hypothetical protein -
NIL_RS08005 1592881..1593240 + 360 WP_187647256.1 hypothetical protein -
NIL_RS08010 1593217..1594236 - 1020 WP_187647257.1 alanine racemase -
NIL_RS08015 1594253..1594591 - 339 WP_187647258.1 type II toxin-antitoxin system PemK/MazF family toxin -
NIL_RS08020 1594578..1594805 - 228 WP_187647259.1 ribbon-helix-helix protein, CopG family -
NIL_RS08025 1595079..1595336 - 258 WP_187647260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL_RS08030 1595329..1595538 - 210 WP_187647261.1 ribbon-helix-helix protein, CopG family Antitoxin
NIL_RS08035 1595841..1597049 - 1209 WP_187647262.1 AAA family ATPase -
NIL_RS08040 1597365..1599086 - 1722 WP_187647263.1 DUF262 domain-containing protein -
NIL_RS08045 1599271..1599672 - 402 WP_197972072.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-83)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-37)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10207.04 Da        Isoelectric Point: 10.1169

>T36557 WP_187647260.1 NZ_AP022826:c1595336-1595079 [Nitratiruptor labii]
MYKVLLDKRVVKDLKKIDKKNREKILAVIEEKIAANPYEGKKLLGDLSDFYRYRVGNYRIIYSIFDDRIEIEIIKIGHRK
EVYSK

Download         Length: 258 bp

>T36557 NZ_AP022826:c1595336-1595079 [Nitratiruptor labii]
ATGTATAAAGTTTTACTCGATAAACGAGTAGTTAAAGATTTGAAAAAAATCGATAAAAAAAACAGAGAAAAGATACTCGC
TGTCATCGAAGAGAAAATCGCTGCAAATCCTTATGAAGGCAAAAAGCTTTTGGGCGATTTGTCCGACTTTTATCGTTATA
GAGTGGGAAATTATAGAATAATATATTCAATTTTTGATGATAGAATCGAAATAGAGATCATAAAAATAGGACATAGAAAA
GAGGTGTACAGCAAGTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8278.64 Da        Isoelectric Point: 5.9110

>AT36557 WP_187647261.1 NZ_AP022826:c1595538-1595329 [Nitratiruptor labii]
MISVRLDKELEKELEEIAKLTKRPKSFFIKEALREYLQDIKDVLEAKKRANDPHRELITLDELKRELDV

Download         Length: 210 bp

>AT36557 NZ_AP022826:c1595538-1595329 [Nitratiruptor labii]
ATGATTAGTGTACGACTTGATAAGGAGTTGGAAAAAGAGTTGGAAGAGATTGCAAAACTCACAAAAAGACCGAAAAGTTT
TTTTATAAAAGAGGCTTTGAGAGAATATTTACAAGATATAAAAGATGTTTTGGAAGCAAAAAAAAGAGCAAACGATCCGC
ATAGAGAGCTTATTACATTAGATGAGCTCAAAAGAGAGCTAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References