Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 887033..887592 Replicon chromosome
Accession NZ_AP022826
Organism Nitratiruptor labii strain HRV44

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NIL_RS04535 Protein ID WP_187648416.1
Coordinates 887257..887592 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NIL_RS04530 Protein ID WP_187648415.1
Coordinates 887033..887263 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL_RS04510 882609..882878 + 270 WP_187648412.1 acylphosphatase -
NIL_RS04515 882899..884329 + 1431 WP_187648413.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NIL_RS04520 884572..886437 + 1866 WP_197972137.1 TRAP transporter large permease subunit -
NIL_RS04525 886447..886947 + 501 WP_187648414.1 HIT domain-containing protein -
NIL_RS04530 887033..887263 + 231 WP_187648415.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NIL_RS04535 887257..887592 + 336 WP_187648416.1 endoribonuclease MazF Toxin
NIL_RS04540 887593..887934 + 342 WP_187648417.1 nucleotide pyrophosphohydrolase -
NIL_RS04545 887971..888744 + 774 WP_187648418.1 hypothetical protein -
NIL_RS04550 888760..889950 - 1191 WP_187648419.1 hypothetical protein -
NIL_RS04555 889999..890259 - 261 WP_187648420.1 hypothetical protein -
NIL_RS04560 890316..891401 - 1086 WP_197972166.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
NIL_RS04565 891513..891818 + 306 WP_187648422.1 MTH1187 family thiamine-binding protein -
NIL_RS04570 891822..892430 - 609 WP_187648423.1 class II aldolase/adducin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-107)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12512.68 Da        Isoelectric Point: 9.0480

>T36556 WP_187648416.1 NZ_AP022826:887257-887592 [Nitratiruptor labii]
MVDYIPSKGDIVWINFNPQSGHEQSGKRPALVISPYKFNKITGFIICCPITSKIKDYPFEVVIEGKIKGAILSDQIKSLD
FRARGISFVEKAKNETLIEVIDKIKLILESQ

Download         Length: 336 bp

>T36556 NZ_AP022826:887257-887592 [Nitratiruptor labii]
ATGGTAGATTATATACCTTCAAAAGGGGATATTGTTTGGATAAATTTCAATCCTCAAAGTGGGCATGAACAGTCTGGAAA
AAGACCGGCACTTGTCATATCTCCTTATAAATTCAATAAAATTACGGGATTTATAATATGTTGTCCAATTACAAGTAAGA
TTAAAGATTATCCTTTTGAAGTAGTGATTGAAGGTAAGATAAAAGGAGCAATACTTAGTGATCAGATCAAAAGTTTAGAT
TTTAGAGCAAGAGGCATAAGTTTTGTTGAAAAGGCAAAAAACGAGACTTTAATAGAAGTTATAGATAAAATAAAACTGAT
TTTAGAGAGTCAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8749.41 Da        Isoelectric Point: 10.5404

>AT36556 WP_187648415.1 NZ_AP022826:887033-887263 [Nitratiruptor labii]
MEAVIKKWGNSLGIRIPKRILDMLNLSENKKVEIKVVGGNIVIKPKKSLDELLSKIEEKNRHKEIDFGKPQGKELW

Download         Length: 231 bp

>AT36556 NZ_AP022826:887033-887263 [Nitratiruptor labii]
ATGGAAGCGGTAATAAAAAAATGGGGCAACAGCTTAGGTATTAGAATCCCAAAAAGGATTTTGGATATGTTGAATTTGAG
TGAAAATAAAAAAGTTGAGATAAAAGTTGTTGGTGGAAATATTGTTATAAAGCCTAAAAAATCATTAGATGAACTTTTAA
GTAAAATTGAAGAAAAAAATCGCCATAAAGAGATAGATTTTGGAAAACCTCAAGGCAAAGAGTTATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References