Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2649699..2650387 Replicon chromosome
Accession NZ_AP022821
Organism Halomonas meridiana strain Slthf1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HMSLTHF_RS12450 Protein ID WP_172416421.1
Coordinates 2649699..2650145 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HMSLTHF_RS12455 Protein ID WP_172416422.1
Coordinates 2650142..2650387 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMSLTHF_RS12440 2646804..2648096 - 1293 WP_172416419.1 restriction endonuclease subunit S -
HMSLTHF_RS12445 2648086..2649651 - 1566 WP_172416420.1 type I restriction-modification system subunit M -
HMSLTHF_RS12450 2649699..2650145 - 447 WP_172416421.1 PIN domain-containing protein Toxin
HMSLTHF_RS12455 2650142..2650387 - 246 WP_172416422.1 Arc family DNA-binding protein Antitoxin
HMSLTHF_RS12460 2650857..2651075 + 219 WP_172416423.1 hypothetical protein -
HMSLTHF_RS12465 2651075..2651827 + 753 WP_172416424.1 P-type conjugative transfer protein TrbJ -
HMSLTHF_RS12470 2651838..2652044 + 207 WP_172416425.1 hypothetical protein -
HMSLTHF_RS12475 2652041..2653552 + 1512 WP_172416426.1 P-type conjugative transfer protein TrbL -
HMSLTHF_RS12480 2653542..2653736 + 195 WP_172416427.1 hypothetical protein -
HMSLTHF_RS12485 2654267..2655031 - 765 WP_172416428.1 ABC transporter ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15886.18 Da        Isoelectric Point: 4.7414

>T36553 WP_172416421.1 NZ_AP022821:c2650145-2649699 [Halomonas meridiana]
MILLDISIISELLRDTPAAQVIEWIDAQPLETLYLSATTVAALQAAVARLPSEERRAHVHAGLEKRLLPLFAGRILPFDQ
SCTRAYAEAITKVEKGGSEILPVDGYIAAIAAVNGLIVAARETAAFEAAGVETINPWQKHSQSDNAAQ

Download         Length: 447 bp

>T36553 NZ_AP022821:c2650145-2649699 [Halomonas meridiana]
ATGATTTTGCTCGACATCAGCATCATCAGCGAGTTGCTGCGCGACACGCCAGCGGCACAGGTCATCGAGTGGATCGATGC
CCAACCGCTGGAAACGCTCTATTTGTCTGCCACCACCGTTGCAGCGTTGCAGGCCGCTGTAGCGCGGCTCCCCTCGGAAG
AACGGCGTGCCCATGTACATGCAGGCCTGGAGAAGCGGCTACTACCCCTATTTGCAGGGCGGATTCTTCCTTTCGACCAG
TCATGCACAAGGGCCTATGCCGAAGCGATAACCAAGGTCGAAAAAGGCGGCAGCGAAATACTTCCGGTAGATGGCTACAT
CGCTGCGATAGCGGCAGTAAACGGTCTGATCGTAGCAGCGCGAGAAACCGCAGCTTTCGAGGCGGCGGGCGTGGAGACCA
TCAACCCGTGGCAAAAACACAGCCAGAGCGATAACGCCGCTCAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8720.09 Da        Isoelectric Point: 7.3197

>AT36553 WP_172416422.1 NZ_AP022821:c2650387-2650142 [Halomonas meridiana]
MAMLTVRNLPDEVHRALRVRAALHGHSMEAEVREILEAAVAPEGRVKLGSLLADIGKQAKLTDKELASFGSTRAGYPVGI
E

Download         Length: 246 bp

>AT36553 NZ_AP022821:c2650387-2650142 [Halomonas meridiana]
ATGGCCATGCTGACTGTTCGCAACCTTCCTGATGAGGTACACCGTGCCTTGCGTGTCCGTGCAGCTCTGCACGGGCACAG
CATGGAGGCCGAGGTGCGCGAGATCCTGGAAGCTGCTGTAGCGCCCGAGGGGCGGGTCAAGCTGGGCTCTCTGCTGGCCG
ACATAGGCAAGCAGGCCAAGCTGACCGATAAAGAGCTGGCATCCTTCGGATCGACTCGCGCTGGGTACCCGGTTGGCATC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References