Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2370215..2370813 Replicon chromosome
Accession NZ_AP022821
Organism Halomonas meridiana strain Slthf1

Toxin (Protein)


Gene name PumA Uniprot ID A0A455VEU3
Locus tag HMSLTHF_RS11190 Protein ID WP_044630744.1
Coordinates 2370215..2370514 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A455V626
Locus tag HMSLTHF_RS11195 Protein ID WP_054641079.1
Coordinates 2370511..2370813 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMSLTHF_RS11175 2366026..2368590 - 2565 WP_172416333.1 ABC transporter permease -
HMSLTHF_RS11180 2368583..2369293 - 711 WP_082051502.1 ABC transporter ATP-binding protein -
HMSLTHF_RS11185 2369391..2370128 + 738 WP_172416334.1 arylesterase -
HMSLTHF_RS11190 2370215..2370514 + 300 WP_044630744.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HMSLTHF_RS11195 2370511..2370813 + 303 WP_054641079.1 putative addiction module antidote protein Antitoxin
HMSLTHF_RS11200 2371019..2371906 - 888 WP_172416335.1 DMT family transporter -
HMSLTHF_RS11205 2371903..2372172 - 270 WP_044628516.1 SelT/SelW/SelH family protein -
HMSLTHF_RS11210 2372330..2373643 + 1314 WP_172416336.1 MFS transporter -
HMSLTHF_RS11215 2373831..2374268 + 438 WP_074210340.1 PAS domain S-box protein -
HMSLTHF_RS11220 2374431..2374643 + 213 WP_044628513.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-91)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11267.85 Da        Isoelectric Point: 10.2220

>T36552 WP_044630744.1 NZ_AP022821:2370215-2370514 [Halomonas meridiana]
MLAIKQTDTYRRWERKLRDSRAKALIAARIFRLANGLTGDVKPVGQGISELRIHHGPGYRVYFKQRGNELVILLCGGDKS
TQQNDIDTAQRLAAEWEES

Download         Length: 300 bp

>T36552 NZ_AP022821:2370215-2370514 [Halomonas meridiana]
ATGCTCGCTATTAAACAAACCGACACTTACCGACGGTGGGAACGCAAGCTCCGCGATTCGCGCGCCAAAGCACTGATTGC
CGCCCGTATTTTCAGGCTGGCCAACGGATTGACTGGCGATGTAAAACCCGTTGGTCAAGGCATCAGTGAACTGCGTATTC
ATCATGGCCCAGGATATCGTGTCTATTTTAAACAACGCGGTAATGAGCTTGTCATCCTGTTGTGTGGTGGCGATAAAAGC
ACTCAGCAAAACGATATCGATACAGCGCAGCGTCTGGCAGCAGAATGGGAGGAATCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10839.31 Da        Isoelectric Point: 4.3766

>AT36552 WP_054641079.1 NZ_AP022821:2370511-2370813 [Halomonas meridiana]
MSDKIYDYDPAAALENDEAIALFLADALETGDATYVAKAMGIVARAKGMTELARETGLSREQLYRSFSEQGNPTLKTMLA
VMRALGMDLTAKPHQEEPAA

Download         Length: 303 bp

>AT36552 NZ_AP022821:2370511-2370813 [Halomonas meridiana]
ATGAGCGATAAGATTTACGACTATGACCCAGCAGCAGCCTTAGAGAACGATGAAGCCATCGCGCTCTTTCTCGCTGATGC
GCTGGAAACCGGAGATGCCACTTATGTTGCTAAAGCGATGGGTATCGTAGCGCGCGCTAAAGGAATGACAGAGCTTGCTC
GCGAAACCGGCCTCTCCCGTGAGCAGCTCTATCGTTCGTTCAGCGAGCAAGGCAATCCAACGCTGAAGACGATGTTGGCC
GTCATGCGTGCACTGGGTATGGACTTGACGGCAAAACCACACCAAGAAGAACCAGCAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A455VEU3

Antitoxin

Source ID Structure
AlphaFold DB A0A455V626

References