Detailed information of TA system TA036550

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1415537..1416069
• Replicon: chromosome
• Accession: NZ_AP022821
• Organism: Halomonas meridiana strain Slthf1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4U3C876
• Locus tag: HMSLTHF_RS06710
• Protein ID: WP_058579745.1
• Coordinates: 1415537..1415830 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A4U3C875
• Locus tag: HMSLTHF_RS06715
• Protein ID: WP_044630393.1
• Coordinates: 1415830..1416069 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMSLTHF_RS16985	1411064..1411432	-	369	WP_197931385.1	tyrosine-type recombinase/integrase	-
HMSLTHF_RS16990	1411414..1411920	-	507	WP_197931386.1	site-specific integrase	-
HMSLTHF_RS06690	1412356..1413549	-	1194	WP_172416098.1	transposase	-
HMSLTHF_RS06695	1413887..1414732	+	846	Protein_1301	transposase family protein	-
HMSLTHF_RS06700	1414765..1415097	+	333	WP_137093728.1	YgjV family protein	-
HMSLTHF_RS06705	1415110..1415271	-	162	Protein_1303	transposase	-
HMSLTHF_RS06710	1415537..1415830	-	294	WP_058579745.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HMSLTHF_RS06715	1415830..1416069	-	240	WP_044630393.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HMSLTHF_RS06720	1416164..1416375	+	212	Protein_1306	Txe/YoeB family addiction module toxin	-
HMSLTHF_RS06725	1416775..1417041	-	267	Protein_1307	DEAD/DEAH box helicase	-
HMSLTHF_RS06730	1417135..1417557	+	423	WP_044630396.1	hypothetical protein	-
HMSLTHF_RS06735	1417568..1418038	+	471	WP_044630397.1	DUF1456 family protein	-
HMSLTHF_RS06740	1418035..1418790	-	756	WP_044630398.1	class I SAM-dependent methyltransferase	-
HMSLTHF_RS06745	1419011..1419421	+	411	WP_044630399.1	DUF4019 domain-containing protein	-
HMSLTHF_RS06750	1419472..1420074	-	603	WP_058579749.1	DedA family protein	-
HMSLTHF_RS06755	1420082..1420939	-	858	WP_172416099.1	DUF1206 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1415011..1415271	260

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11322.97 Da
• Isoelectric Point: 10.4460

>T36550 WP_058579745.1 NZ_AP022821:c1415830-1415537 [Halomonas meridiana]
MRPYLLTSSARKDVVEIGRFTTEKWGKRQRDTYLRQLDDAFKLLARQPDIGRDTGDIKPGYKKFSQGSHVIFYRAGTESR
IVVIRILHNSMDVEQHL

Nucleotide

• Length: 294 bp

>T36550 NZ_AP022821:c1415830-1415537 [Halomonas meridiana]
ATGCGTCCATACCTGCTCACTTCCTCTGCCCGAAAAGACGTTGTCGAGATAGGCCGCTTCACCACCGAAAAGTGGGGAAA
GCGCCAACGCGATACGTACCTCAGGCAGCTTGACGATGCTTTCAAGCTGCTCGCTCGCCAACCTGATATTGGCCGCGATA
CGGGTGACATAAAACCAGGGTACAAAAAGTTCAGTCAGGGCAGTCATGTTATCTTTTACAGAGCCGGTACGGAATCCAGG
ATCGTTGTCATCCGAATTCTCCACAACAGTATGGATGTGGAGCAGCATCTTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8875.88 Da
• Isoelectric Point: 4.3041

>AT36550 WP_044630393.1 NZ_AP022821:c1416069-1415830 [Halomonas meridiana]
MARNTSITLGPHFDEFIAIQVEKGRYGSVSEVVRAGLRLLEETESKLERLQRLLDEGEQSGIAEYSLESVITELDNEAH

Nucleotide

• Length: 240 bp

>AT36550 NZ_AP022821:c1416069-1415830 [Halomonas meridiana]
ATGGCTAGAAATACCAGCATTACACTCGGCCCCCACTTTGATGAGTTTATAGCCATTCAGGTTGAAAAGGGCCGCTATGG
CTCGGTGAGCGAGGTGGTACGTGCCGGACTGCGTCTGCTTGAAGAAACGGAAAGTAAGCTTGAACGGCTCCAACGCCTTC
TGGATGAAGGCGAACAGAGCGGAATCGCAGAGTATTCCCTTGAAAGCGTTATTACAGAACTGGACAACGAAGCTCACTGA

Structures

Toxin

• AlphaFold DB: A0A4U3C876

Antitoxin

• AlphaFold DB: A0A4U3C875