Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yoeB-relB/YoeB-YefM |
| Location | 950723..951225 | Replicon | chromosome |
| Accession | NZ_AP022821 | ||
| Organism | Halomonas meridiana strain Slthf1 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A4U3CA92 |
| Locus tag | HMSLTHF_RS04555 | Protein ID | WP_044627928.1 |
| Coordinates | 950723..950977 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A510J541 |
| Locus tag | HMSLTHF_RS04560 | Protein ID | WP_044627927.1 |
| Coordinates | 950974..951225 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HMSLTHF_RS04515 | 946994..947847 | + | 854 | WP_137095258.1 | IS5 family transposase | - |
| HMSLTHF_RS04520 | 947968..948270 | + | 303 | WP_054640923.1 | hypothetical protein | - |
| HMSLTHF_RS04525 | 948771..949085 | - | 315 | WP_044630801.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HMSLTHF_RS04530 | 949088..949324 | - | 237 | WP_044630802.1 | addiction module protein | - |
| HMSLTHF_RS04535 | 949520..949777 | + | 258 | WP_022992576.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HMSLTHF_RS04540 | 949765..950067 | + | 303 | WP_061332717.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HMSLTHF_RS04545 | 950213..950455 | + | 243 | WP_044627930.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HMSLTHF_RS04550 | 950452..950715 | + | 264 | WP_044627929.1 | Txe/YoeB family addiction module toxin | - |
| HMSLTHF_RS04555 | 950723..950977 | - | 255 | WP_044627928.1 | Txe/YoeB family addiction module toxin | Toxin |
| HMSLTHF_RS04560 | 950974..951225 | - | 252 | WP_044627927.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| HMSLTHF_RS04565 | 951283..951498 | - | 216 | WP_137093240.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| HMSLTHF_RS04570 | 951567..952976 | + | 1410 | WP_062359340.1 | mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase | - |
| HMSLTHF_RS04575 | 952987..953337 | - | 351 | WP_062359339.1 | hypothetical protein | - |
| HMSLTHF_RS04580 | 953350..954282 | - | 933 | WP_172416002.1 | lysophospholipid acyltransferase family protein | - |
| HMSLTHF_RS04585 | 954286..954681 | - | 396 | WP_044627923.1 | DUF4870 domain-containing protein | - |
| HMSLTHF_RS04590 | 954802..955185 | - | 384 | WP_044627922.1 | VOC family protein | - |
| HMSLTHF_RS04595 | 955225..955863 | + | 639 | WP_137093238.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 946994..947362 | 368 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10182.73 Da Isoelectric Point: 9.8876
>T36549 WP_044627928.1 NZ_AP022821:c950977-950723 [Halomonas meridiana]
MKLIFSENAWEDYLYWQKTDKKILNRINKLIKETKREPFEGVGKPEPLKHSLAGYWSRRINEEHRIAYKVTDDALLIAQL
RYHH
MKLIFSENAWEDYLYWQKTDKKILNRINKLIKETKREPFEGVGKPEPLKHSLAGYWSRRINEEHRIAYKVTDDALLIAQL
RYHH
Download Length: 255 bp
>T36549 NZ_AP022821:c950977-950723 [Halomonas meridiana]
ATGAAACTCATCTTCTCCGAGAACGCCTGGGAAGACTATCTGTACTGGCAGAAAACCGACAAAAAGATACTTAACCGAAT
CAACAAACTGATCAAAGAGACCAAACGAGAACCGTTCGAAGGTGTTGGCAAACCAGAGCCCCTCAAACACAGCCTCGCCG
GGTACTGGTCTCGCCGGATCAACGAAGAACACCGAATAGCTTACAAAGTCACGGATGACGCTTTGCTTATCGCCCAGCTC
CGGTATCACCACTGA
ATGAAACTCATCTTCTCCGAGAACGCCTGGGAAGACTATCTGTACTGGCAGAAAACCGACAAAAAGATACTTAACCGAAT
CAACAAACTGATCAAAGAGACCAAACGAGAACCGTTCGAAGGTGTTGGCAAACCAGAGCCCCTCAAACACAGCCTCGCCG
GGTACTGGTCTCGCCGGATCAACGAAGAACACCGAATAGCTTACAAAGTCACGGATGACGCTTTGCTTATCGCCCAGCTC
CGGTATCACCACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9296.52 Da Isoelectric Point: 4.4750
>AT36549 WP_044627927.1 NZ_AP022821:c951225-950974 [Halomonas meridiana]
MDAISYTAARTNLAKTMEQVCEDHSPVIITRNKSQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE
MDAISYTAARTNLAKTMEQVCEDHSPVIITRNKSQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE
Download Length: 252 bp
>AT36549 NZ_AP022821:c951225-950974 [Halomonas meridiana]
ATGGATGCCATTAGCTACACAGCCGCTAGAACCAATCTAGCAAAAACCATGGAGCAGGTCTGTGAAGACCATTCCCCTGT
GATCATCACCCGGAACAAGTCGCAGTCCGTGGTAATGATCTCCCTAGAGGACTACGAGGCGCTGCAAGAGACTGCATACC
TTCTGCGCGCACCAAAAAACGCACGGCGTTTGCTGGAATCCGTTGCCGAGCTGGAGCAAGGCGGTGGTCAAGAAAAGGAA
CTTCTTGAATGA
ATGGATGCCATTAGCTACACAGCCGCTAGAACCAATCTAGCAAAAACCATGGAGCAGGTCTGTGAAGACCATTCCCCTGT
GATCATCACCCGGAACAAGTCGCAGTCCGTGGTAATGATCTCCCTAGAGGACTACGAGGCGCTGCAAGAGACTGCATACC
TTCTGCGCGCACCAAAAAACGCACGGCGTTTGCTGGAATCCGTTGCCGAGCTGGAGCAAGGCGGTGGTCAAGAAAAGGAA
CTTCTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4U3CA92 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A510J541 |