Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 949520..950067 | Replicon | chromosome |
| Accession | NZ_AP022821 | ||
| Organism | Halomonas meridiana strain Slthf1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A455V9X0 |
| Locus tag | HMSLTHF_RS04540 | Protein ID | WP_061332717.1 |
| Coordinates | 949765..950067 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U7NTA2 |
| Locus tag | HMSLTHF_RS04535 | Protein ID | WP_022992576.1 |
| Coordinates | 949520..949777 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HMSLTHF_RS04510 | 945415..946917 | + | 1503 | WP_172416001.1 | N-6 DNA methylase | - |
| HMSLTHF_RS04515 | 946994..947847 | + | 854 | WP_137095258.1 | IS5 family transposase | - |
| HMSLTHF_RS04520 | 947968..948270 | + | 303 | WP_054640923.1 | hypothetical protein | - |
| HMSLTHF_RS04525 | 948771..949085 | - | 315 | WP_044630801.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HMSLTHF_RS04530 | 949088..949324 | - | 237 | WP_044630802.1 | addiction module protein | - |
| HMSLTHF_RS04535 | 949520..949777 | + | 258 | WP_022992576.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HMSLTHF_RS04540 | 949765..950067 | + | 303 | WP_061332717.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HMSLTHF_RS04545 | 950213..950455 | + | 243 | WP_044627930.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HMSLTHF_RS04550 | 950452..950715 | + | 264 | WP_044627929.1 | Txe/YoeB family addiction module toxin | - |
| HMSLTHF_RS04555 | 950723..950977 | - | 255 | WP_044627928.1 | Txe/YoeB family addiction module toxin | - |
| HMSLTHF_RS04560 | 950974..951225 | - | 252 | WP_044627927.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| HMSLTHF_RS04565 | 951283..951498 | - | 216 | WP_137093240.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| HMSLTHF_RS04570 | 951567..952976 | + | 1410 | WP_062359340.1 | mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase | - |
| HMSLTHF_RS04575 | 952987..953337 | - | 351 | WP_062359339.1 | hypothetical protein | - |
| HMSLTHF_RS04580 | 953350..954282 | - | 933 | WP_172416002.1 | lysophospholipid acyltransferase family protein | - |
| HMSLTHF_RS04585 | 954286..954681 | - | 396 | WP_044627923.1 | DUF4870 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 931171..950455 | 19284 | |
| - | flank | IS/Tn | - | - | 946994..947362 | 368 | |
| - | inside | Integron | - | - | 947842..950455 | 2613 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11663.41 Da Isoelectric Point: 4.5702
>T36548 WP_061332717.1 NZ_AP022821:949765-950067 [Halomonas meridiana]
MAEVIWTEPALQELDAIAEYIALDNPVAASHLVQEVFDKTERLEDFPQSGRIPPELPNSVYREVVVPPCRIFYREDKKRV
LVLYVMREERQLRAYMLGNS
MAEVIWTEPALQELDAIAEYIALDNPVAASHLVQEVFDKTERLEDFPQSGRIPPELPNSVYREVVVPPCRIFYREDKKRV
LVLYVMREERQLRAYMLGNS
Download Length: 303 bp
>T36548 NZ_AP022821:949765-950067 [Halomonas meridiana]
ATGGCTGAAGTAATCTGGACGGAGCCTGCTCTGCAAGAACTGGATGCCATCGCTGAGTACATTGCTCTGGATAATCCTGT
TGCCGCAAGTCATCTGGTCCAAGAAGTTTTCGATAAGACCGAGCGCTTGGAAGATTTTCCCCAATCCGGACGGATTCCTC
CAGAGCTCCCTAATTCGGTATACAGGGAGGTAGTGGTTCCACCGTGTCGCATTTTTTATCGTGAGGATAAGAAGCGGGTT
CTCGTCCTCTATGTCATGCGAGAGGAGCGGCAGCTTCGTGCGTACATGCTTGGGAACAGCTAA
ATGGCTGAAGTAATCTGGACGGAGCCTGCTCTGCAAGAACTGGATGCCATCGCTGAGTACATTGCTCTGGATAATCCTGT
TGCCGCAAGTCATCTGGTCCAAGAAGTTTTCGATAAGACCGAGCGCTTGGAAGATTTTCCCCAATCCGGACGGATTCCTC
CAGAGCTCCCTAATTCGGTATACAGGGAGGTAGTGGTTCCACCGTGTCGCATTTTTTATCGTGAGGATAAGAAGCGGGTT
CTCGTCCTCTATGTCATGCGAGAGGAGCGGCAGCTTCGTGCGTACATGCTTGGGAACAGCTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9901.44 Da Isoelectric Point: 8.5042
>AT36548 WP_022992576.1 NZ_AP022821:949520-949777 [Halomonas meridiana]
MKVELVTNLKRQATKILADLHLSKEPILITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK
MKVELVTNLKRQATKILADLHLSKEPILITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK
Download Length: 258 bp
>AT36548 NZ_AP022821:949520-949777 [Halomonas meridiana]
ATGAAAGTTGAGCTTGTTACGAACCTCAAGCGCCAAGCCACAAAGATTCTGGCAGATCTGCACTTGTCTAAAGAGCCGAT
ACTGATCACGGAGCATGGTCAGCCATCGGCATATCTTGTCGATGTGCAGGATTACGAGTTTATGCAGCGCCGACTTGAGC
TGCTTGAGGGGCTCTCACGGGGAGAGCGTGCTGTACTTGAGGGAAGAACGTACAGCCAAAGTGAGGCCAGGGAGAAAATG
AGTAAATGGCTGAAGTAA
ATGAAAGTTGAGCTTGTTACGAACCTCAAGCGCCAAGCCACAAAGATTCTGGCAGATCTGCACTTGTCTAAAGAGCCGAT
ACTGATCACGGAGCATGGTCAGCCATCGGCATATCTTGTCGATGTGCAGGATTACGAGTTTATGCAGCGCCGACTTGAGC
TGCTTGAGGGGCTCTCACGGGGAGAGCGTGCTGTACTTGAGGGAAGAACGTACAGCCAAAGTGAGGCCAGGGAGAAAATG
AGTAAATGGCTGAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A455V9X0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A455VBQ8 |